Use of Gas Chromatomass Spectroscopy for Analysis of Salicylate Contents in Plasma from Patients with Cerebrovascular Diseases Taking Aspirin as Antiaggregant Therapy
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A chromatomass spectrometric method for assay of salicylic and acetylsalicylic acids in human plasma was developed and metrologically validated. The method measured salicylic and acetylsalicylic acid contents in plasma samples from 26 patients with cerebrovascular diseases (CVD) taking aspirin constantly at doses of 75 – 100 mg/day as antiaggregant therapy for primary or secondary prophylaxis of vascular events. Patients whose samples contained acetylsalicylic acid demonstrated more marked pharmacological responses to antiaggregant therapy.
Keywordspharmacoresistance salicylates aspirin antiaggregants treatment monitoring mass spectroscopy gas chromatography derivatization
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