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Synthesis, Characterization and Antimicrobial Activity of Bis(Phthalimido)Piperazine and its Derivatives: a New Class of Bioactive Molecules with Enhanced Safety and Efficacy

  • Afeefa Aslam
  • Muhammad Azhar Abbas
  • Mudassir IqbalEmail author
  • Sajid Bashir
  • Tahir Mehmood
  • Joerg Kressler
Article
  • 22 Downloads

Piperazine rings are important heterocyclic targets in organic synthesis and are useful synthetic intermediates or intricate parts of biologically active molecules. In our efforts, a series of piperazine derivatives has been prepared discovering new classes of antimicrobial agents, including bis(phthalimido)piperazine, bis(3-aminopropyl) piperazine, 2,3-dihydro-phthalazine-1,4-dione, and bis(3,4-aminophenol)piperazine. The synthesized antimicrobial agents have been studied using various spectroscopic techniques. Furthermore, these compounds have been screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. Three compounds exhibited mild to good antibacterial activity, but somewhat lower antifungal activity against tested microbial strains.

Keywords

piperazine derivatives bis(phthalimido)piperazine antimicrobial activity 

Notes

Acknowledgments

The authors would like to thank the Vice Chancellor of the University of Sargodha and Prof. J. Kressler (Institute fur Chemie, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany) for their moral and excellent technical support regarding this work.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Afeefa Aslam
    • 1
  • Muhammad Azhar Abbas
    • 2
  • Mudassir Iqbal
    • 3
    Email author
  • Sajid Bashir
    • 1
  • Tahir Mehmood
    • 2
    • 4
  • Joerg Kressler
    • 5
  1. 1.Department of PharmacyUniversity of SargodhaSargodhaPakistan
  2. 2.Department of ChemistryUniversity of SargodhaSargodhaPakistan
  3. 3.Department of Chemistry, School of Natural Sciences (SNS)National University of Sciences and Technology (NUST)IslamabadPakistan
  4. 4.Institute of Biochemistry and BiotechnologyUniversity of Veterinary and Animal Sciences (UVAS)LahorePakistan
  5. 5.Department of Chemistry, Institute of Physical ChemistryMartin Luther University of Halle-WittenbergHalle (Saale)Germany

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