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Validation of a GC-MS Method for Quantitative Determination of Cyclohexanone by Oxidative Cleavage

  • E. V. Podrezova
  • M. S. Lar’kinaEmail author
  • M. S. Yusubov
  • M. V. Belousov
  • M. K. Zamanova
  • S. V. Krivoshchekov
Article
  • 7 Downloads

A GC method for quantitative determination of cyclohexanone by oxidative cleavage was proposed. The research was aimed at the development of a simple, rapid, and effective GC method for quantitative analysis of cyclohexanone in a reaction mixture. Chlorobenzene was used as an internal standard. Qualitative analysis compared mass spectra obtained for each component with mass spectra from the National Institute of Standards and Technology (NIST) database. The method was validated for specificity, linearity, accuracy, robustness, repeatability, and intralaboratory precision.

Keywords

cyclohexanone quantitative determination oxidative cleavage validation gas chromatography internal standard 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • E. V. Podrezova
    • 1
  • M. S. Lar’kina
    • 2
    Email author
  • M. S. Yusubov
    • 1
    • 2
  • M. V. Belousov
    • 2
  • M. K. Zamanova
    • 1
  • S. V. Krivoshchekov
    • 1
    • 2
  1. 1.Tomsk State Polytechnic UniversityTomskRussia
  2. 2.Siberian State Medical UniversityTomskRussia

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