Joint Mechanical Processing of a Drug Substance with Enterosorbent

  • N. S. IvanovaEmail author
  • T. S. Pak
  • É. L. Kristalovich
  • D. B. Takhtaganova

A selective enterosorbent (ES) based on natural silk fibroin with detoxification properties superior to those of traditional carbon sorbents (SKN-2K, SKN-4M) was proposed. The ES could be used as a matrix for drugs and a platform for new dosage forms to enhance the sanitizing effect of the proposed ES. Inclusion complexes of the ES with benzimidazolyl-2-methylcarbamate hydrochloride (I) were obtained and investigated. H-bonds were shown to form during the reaction of ES with I.


enterosorbent mechanical activation benzimidazol-2-ylmethylcarbamate hydrochloride inclusion complexes difference spectrum supramolecular structure 


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Authors and Affiliations

  • N. S. Ivanova
    • 1
    Email author
  • T. S. Pak
    • 1
  • É. L. Kristalovich
    • 2
  • D. B. Takhtaganova
    • 2
  1. 1.Pskov State UniversityPskovRussia
  2. 2.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussia

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