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Dissolution of Ketoprofen from Poly(Ethylene Glycol) Solid Dispersions

  • A. V. BelyatskayaEmail author
  • I. I. KrasnyukJr
  • I. I. Krasnyuk
  • O. I. Stepanova
  • T. M. Kosheleva
  • T. P. Kudinova
  • A. N. Vorob’ev
  • M. M. Maryanyan
Article
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The effect of solid dispersions (SDs) on the solubility of the nonsteroidal anti-inflammatory drug ketoprofen was determined. Ketoprofen and its SDs with poly(ethylene glycol) PEG-400, -1000, -1500, -2000, and -3000 were studied. Dissolution of ketoprofen from the SDs increased by 1.2 – 1.8 times; the dissolution rate, by 1.7 – 2.4 times. The improved release of ketoprofen from the SDs was proposed to be due to several factors such as solubilization and amorphization of the compound and formation of intermolecular H-bonds. The results could be used to develop rapidly dissolving ketoprofen solid dosage forms.

Keywords

solid dispersions dissolution ketoprofen poly(ethylene glycol) 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. V. Belyatskaya
    • 1
    Email author
  • I. I. KrasnyukJr
    • 1
  • I. I. Krasnyuk
    • 1
  • O. I. Stepanova
    • 1
  • T. M. Kosheleva
    • 1
  • T. P. Kudinova
    • 1
  • A. N. Vorob’ev
    • 2
  • M. M. Maryanyan
    • 1
  1. 1.I. M. Sechenov First Moscow State Medical University (Sechenov University)Ministry of Health of RussiaMoscowRussia
  2. 2.People’s Friendship University of Russia (RUDN University)MoscowRussia

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