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Pharmaceutical Chemistry Journal

, Volume 52, Issue 12, pp 992–995 | Cite as

Antiarrhythmic Activity of the Flavonoid Fraction of Plantago Major L. Extract

  • Sh. S. KhushmatovEmail author
  • R. R. Makhmudov
Article
  • 11 Downloads

Antiarrhythmic activity of the flavonoid fraction of Plantago major L. extract (0.05 mg/mL) was studied. The studied fractions were found to lower the frequency of rat cardiac papillary muscle contractions with aconitine-induced (1 μM) arrythmia in vitro. An analysis of literature and experimental data suggested that the antiarrhythmic effects of the studied flavonoid fractions may have been related to functional modulation of Na+- and Ca2+-channels in cardiomyocytes.

Keywords

flavonoids papillary muscle Plantago major L. extract arrhythmia 

Notes

Acknowledgments

The work was financially supported by the Basic Research Program of the AS RUz (Project FA-F6-T083, Discovery and Characterization of Biologically Active Compounds as Ca2+-homeostasis Modulators in Cardiac and Smooth Muscle Cells).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.A. S. Sadykov Institute of Bioorganic ChemistryAcademy of Sciences of the Republic of UzbekistanTashkentUzbekistan

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