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Pharmaceutical Chemistry Journal

, Volume 52, Issue 11, pp 912–916 | Cite as

Synthesis, Antimicrobial Properties, and Toxicity of a Nanobiocomposite Based on Ag(0) Particles and Poly(1-Vinyl-1,2,4-Triazole)

  • L. M. SosedovaEmail author
  • M. A. Novikov
  • E. A. Titov
  • A. S. Pozdnyakov
  • S. A. Korzhova
  • T. G. Ermakova
  • G. F. Prozorova
Article

The synthesis of a water-soluble polymer nanocomposite with Ag(0) particles encapsulated in a poly(1-vinyl-1,2,4-triazole) matrix is reported. The nanocomposite contains isolated spherical Ag(0) particles sized from 2 to 8 nm that are uniformly distributed in the polymer matrix and have a characteristic plasmonic absorption maximum at 412 nm. The new nanocomposite belongs to marginally hazardous category 4. The structural morphology of animal brain tissue is not disturbed after subacute intragastric injection. The bacteriostatic concentration of the nanocomposite varies in the range 0.5 – 32 μg/mL; bactericidal, 1 – 64 μg/mL.

Keywords

polymer nanocomposites poly(1-vinyl-1,2,4-triazole) Ag(0) nanoparticles experimental research subacute administration white rats organ tissue morphology 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. M. Sosedova
    • 1
    Email author
  • M. A. Novikov
    • 1
  • E. A. Titov
    • 1
  • A. S. Pozdnyakov
    • 2
  • S. A. Korzhova
    • 2
  • T. G. Ermakova
    • 2
  • G. F. Prozorova
    • 2
  1. 1.East-Siberian Medico-Ecological Research InstituteAngarskRussia
  2. 2.A. E. Favorsky Irkutsk Institute of ChemistrySiberian Branch, Russian Academy of SciencesIrkutskRussia

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