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Synthesis and Anti-Inflammatory Activity of Tyrosol and Its Structural Analogs

  • A. P. Krysin
  • T. G. Tolstikova
  • M. P. Dolgikh
  • E. E. Shul’tsEmail author
  • L. M. Pokrovskii
Article

The anti-inflammatory activity of tyrosol and 12 structural analogs including 3 new compounds was determined. Several structure-activity (anti-inflammatory) relationships were found. Adding a tert-butyl substituent to the aromatic ring and increasing the length of the alkyl chain decreased the anti-inflammatory activity. Pronounced antiulcer activity was found for p-tyrosol.

Keywords

p-tyrosol hydroxyalkylphenols anti-inflammatory and antiulcer activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • A. P. Krysin
    • 1
  • T. G. Tolstikova
    • 1
  • M. P. Dolgikh
    • 1
  • E. E. Shul’ts
    • 1
    Email author
  • L. M. Pokrovskii
    • 1
  1. 1.N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian BranchRussian Academy of SciencesNovosibirskRussia

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