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Pharmaceutical Chemistry Journal

, Volume 52, Issue 8, pp 711–715 | Cite as

Synthesis and Antimicrobial, Antiprotozoal, and Fungistatic Activity of [5-(Amino-, Acylamino-, and 2-Pyridylmethylamino)-1-Alkylbenzimidazol-2-yl]Diphenylmethanols

  • Yu. V. Koshchienko
  • Yu. D. Drobin
  • A. A. Zubenko
  • D. A. Timoshevskii
  • L. N. Fetisov
  • A. N. Bodryakov
Article
  • 82 Downloads

5-(Amino- and 2-pyridylmethylamino)-1-alkylbenzimidazoles treated sequentially with butyllithium and benzophenone synthesized [5-(amino- and 2-pyridylmethylamino)-1-alkylbenzimidazol-2-yl]diphenylmethanols. (5-Amino-1-methylbenzimidazol-2-yl)diphenylmethanol was converted by acyl chlorides into (5-acylamino-1-methylbenzimidazol-2-yl)diphenylmethanols. The products were shown to possess bacteriostatic activity against Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli), antiprotozoal activity against the ciliate Colpoda steinii, and fungicidal activity against Penicillium italicum.

Keywords

[5-(amino-and 2-pyridylmethylamino)-1-alkylbenzimidazol-2-yl]diphenylmethanols (5-acylamino-1-methylbenzimidazol-2-yl)diphenylmethanols synthesis antibacterial, antiprotozoal, and fungistatic activity 

Notes

Acknowledgments

The work was financially supported by the Ministry of Education and Science of the RF under a state task on Project No. 1895. The work used equipment at the Molecular Spectroscopy CUC, RIPOC, SFU.

References

  1. 1.
    Y. Bansal and O. Silakari, Bioorg. Med. Chem., 20, 6208 – 6236 (2012).Google Scholar
  2. 2.
    B. Narasimhan, D. Sharma, and P. Kumar, Med. Chem. Res., 21(3), 269 – 283 (2012).CrossRefGoogle Scholar
  3. 3.
    N. Singh, A. Pandurangan, K. Rana, et al., Int. Curr. Pharm. J., 1(5), 119 – 127 (2012).CrossRefGoogle Scholar
  4. 4.
    H. E. Schultze, K. Heide, and H. Haupt, Nature, 200, 1101 – 1103 (1963).Google Scholar
  5. 5.
    D. G. O’Sullivan and A. K. Wallis, Nature, 198, 1270 – 1273 (1963).Google Scholar
  6. 6.
    I. Tamm, H. J. Eggers, R. Bablanian, et al., Nature, 223, 785 – 788 (1969).Google Scholar
  7. 7.
  8. 8.
  9. 9.
    B. A. Tertov, N. F. Vanieva, A. V. Koblik, et al., Khim.-farm. Zh., 7(8), 27 – 29 (1973).Google Scholar
  10. 10.
    E. I. Elnima, M. U. Zubair, and A. A. Al-badr, Antimicrob. Agents Chemother., 19(1), 29 – 32 (1981).CrossRefGoogle Scholar
  11. 11.
    K. J. Okolotowicz, P. Bushway, M. Lanier, et al., Bioorg. Med. Chem., 23, 5282 – 5292 (2015).Google Scholar
  12. 12.
    G. A. Kilcigil and N. Altanlar, Turk. J. Chem., 30, 223 – 228 (2006).Google Scholar
  13. 13.
    F. Montanari, Gazz. Chim. Ital., 85, 981 – 988 (1955).Google Scholar
  14. 14.
  15. 15.
    Determination of Microorganism Sensitivity to Antibacterial Drugs. Methodical Instructions [in Russian], MUK 4.2.1890-04, Moscow (2004).Google Scholar
  16. 16.
    G. N. Pershin, Methods of Experimental Chemotherapy [in Russian], Meditsina, Moscow (1971), pp. 100 – 106.Google Scholar
  17. 17.
    L. N. Fetisov, A. A. Zubenko, A. N. Bodryakov, et al., in: Abstracts of Papers of the International Parasitological Symposium “Current Problems of General and Special Parasitology” [in Russian], (2012); publ. in the informational-analytical journal Vopr. Normativno-Prav. Regul. Vet., No. 4 / 1, 70 – 73 (2012); ISSN 2072 – 6023.Google Scholar
  18. 18.
    A. N. Mironov, Handbook for Preclinical Drug Trials, Part 1, Ministry of Health and Social Development of the RF, Nauchnyi Tsentr Ekspertizy Sredstv Meditsinskogo Primeneniya, Moscow (2012).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Yu. V. Koshchienko
    • 1
  • Yu. D. Drobin
    • 2
  • A. A. Zubenko
    • 2
  • D. A. Timoshevskii
    • 1
  • L. N. Fetisov
    • 2
  • A. N. Bodryakov
    • 2
  1. 1.Research Institute of Physical and Organic ChemistrySouthern Federal UniversityRostov-on-DonRussia
  2. 2.North-Caucasian Regional Scientific Research Veterinary InstituteNovocherkasskRussia

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