Pharmaceutical Chemistry Journal

, Volume 50, Issue 9, pp 600–602 | Cite as

Local Anesthetic Activity of a Promising Piperidine Derivative (LAS-54) in Combination with Epinephrine

  • G. M. Pichkhadze
  • G. S. Smagulova
  • D. M. Kadyrova
  • K. D. Praliev
  • V. K. Yu

Results from studies of the local anesthetic activity of LAS-54 [4-(benzoyloxy)-3-butoxypiperidinium chloride] (synthesized at the Laboratory of the Chemistry of Synthetic and Natural Drugs, Bekturov Institute of Chemical Sciences) in combination with epinephrine are presented. It was found that joint application of the vasoconstrictor with LAS-54, especially at low concentrations, prolonged infiltration, conduction, and spinal anesthesia.


conduction, infiltration, and spinal anesthesia piperidine vasoconstrictor epinephrine 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • G. M. Pichkhadze
    • 1
  • G. S. Smagulova
    • 1
  • D. M. Kadyrova
    • 1
  • K. D. Praliev
    • 2
  • V. K. Yu
    • 2
  1. 1.S. D. Asfendiyarov Kazakh National Medical UniversityAlmatyKazakhstan
  2. 2.A. B. Bekturov Institute of Chemical SciencesMinistry of Education and Science of the Republic of KazakhstanAlmatyKazakhstan

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