Advertisement

Pharmaceutical Chemistry Journal

, Volume 50, Issue 3, pp 152–155 | Cite as

Experimental Study of the Biocompatibility of Soft Tissues and a Finely Dispersed Sorbent Containing Silver

  • T. V. Popova
  • T. G. Tolstikova
  • A. Yu. Letyagin
  • L. N. Rachkovskaya
  • V. A. Burmistrov
Article
  • 51 Downloads

The physicochemical and biological properties of a new finely dispersed Si- and Al-containing sorbent are presented. Its modification using silver nanoclusters immobilized on the sorbent-particle surface is described. The parameters of the sorbent porous structure, its sorption activity, and the rate of silver release from the sorbent surface in contact with a liquid medium are determined. Both the sorbent matrix and the original silver-modified sorbent are well tolerated by experimental animals upon intramuscular administration and cause no changes in the behavior, weight, and appearance of the animals. Results from studies of the leukocyte, platelet, and red-blood-cell pools of peripheral blood also confirm that the sorbents are biocompatible with body tissues.

Keywords

silver-containing sorbents silver nanoclusters biocompatibility 

References

  1. 1.
    Yu. I. Borodin, V. A. Trufakin, V. V. Astashov, et al., Methods of Endoecological Rehabilitation [in Russian], Izd. Dom Manuskript, Novosibirsk (1999), pp. 49 – 52.Google Scholar
  2. 2.
    M. I. Loseva, G. S. Soldatova, T. I. Pospelova, et al., Problems in Experimental Clinical and Prophylactic Lymphology. Proceedings of an International Symposium, Novosibirsk (2000), pp. 179 – 182.Google Scholar
  3. 3.
    L. N. Rachkovskaya, A. Yu. Letyagin, V. A. Burmistrov, et al., Sib. Nauchn. Med. Zh., 35(2), 47 – 54 (2015).Google Scholar
  4. 4.
    L. N. Rachkovskaya, Carbon-mineral Sorbents for Medicine [in Russian], Sib. Otd. Ross. Akad. S?kh. Nauk, Novosibirsk (1996), pp. 5 – 8.Google Scholar
  5. 5.
    L. I. Blagitko, A. S. Polyakevich, A. I. Brombin, et al., Use of Silver Preparations in Medicine [in Russian], ZAO Vektor-Best, Novosibirsk (2002), pp. 20 – 25.Google Scholar
  6. 6.
    N. N. Shkil’, N. A. Shkil’, V. A. Burmistrov, et al., Nauchn. Zh. KubGAU, 68(04), 46 (2001).Google Scholar
  7. 7.
    GOST 4453–74. Active absorbing powder charcoal. Specifications [in Russian], Moscow (1992).Google Scholar
  8. 8.
    GOST 6613–86. Square mesh woven wire cloths. Specifications (with Change No. 1) [in Russian], Moscow (1986).Google Scholar
  9. 9.
    A. D. Nozdrachev and E. L. Polyakov, Rat Anatomy [in Russian], Lan’, St. Petersburg (2001), pp. 73 – 75.Google Scholar
  10. 10.
    A. N. Mironov and N. D. Bunyatyan, Handbook for Preclinical Drug Trials [in Russian], Part 1, Grif i K, Tula (2012), pp. 21 – 23.Google Scholar
  11. 11.
    Zh. Dolaev, A. Soltangulov, E. Nurmakhan, et al., Usp. Sovrem. Estestvozn., No. 9, 29 – 30 (2013).Google Scholar
  12. 12.
    T. G. Demchenko and K. M. Burova, Usp. Sovrem. Estestvozn., No. 9, 28 – 29 (2013).Google Scholar
  13. 13.
    S. A. Lugovskaya, Laboratoriya. Zh. Dlya Vrachei, No. 5, 7 – 9 (1997).Google Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Institute of Clinical and Experimental LymphologyNovosibirskRussia
  2. 2.N. N. Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Branch, Russian Academy of SciencesNovosibirskRussia

Personalised recommendations