Pharmaceutical Chemistry Journal

, Volume 50, Issue 3, pp 152–155 | Cite as

Experimental Study of the Biocompatibility of Soft Tissues and a Finely Dispersed Sorbent Containing Silver

  • T. V. Popova
  • T. G. Tolstikova
  • A. Yu. Letyagin
  • L. N. Rachkovskaya
  • V. A. Burmistrov

The physicochemical and biological properties of a new finely dispersed Si- and Al-containing sorbent are presented. Its modification using silver nanoclusters immobilized on the sorbent-particle surface is described. The parameters of the sorbent porous structure, its sorption activity, and the rate of silver release from the sorbent surface in contact with a liquid medium are determined. Both the sorbent matrix and the original silver-modified sorbent are well tolerated by experimental animals upon intramuscular administration and cause no changes in the behavior, weight, and appearance of the animals. Results from studies of the leukocyte, platelet, and red-blood-cell pools of peripheral blood also confirm that the sorbents are biocompatible with body tissues.


silver-containing sorbents silver nanoclusters biocompatibility 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Institute of Clinical and Experimental LymphologyNovosibirskRussia
  2. 2.N. N. Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Branch, Russian Academy of SciencesNovosibirskRussia

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