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Pharmaceutical Chemistry Journal

, Volume 49, Issue 10, pp 680–682 | Cite as

Analgesic Effect of Several Nonsteroidal Anti-Inflammatory Drug Nanoaerosols

  • S. V. An’kov
  • T. G. TolstikovaEmail author
  • A. A. Onishchuk
  • M. V. Khvostov
  • I. V. Sorokina
  • A. M. Baklanov
  • V. M. Fomin
  • V. V. Boldyrev
Article
  • 69 Downloads

The analgesic activities of nanoaerosols of the nonsteroidal anti-inflammatory drugs indomethacin, butadion, and diclofenac were studied. It was found that nanoaerosol delivery of these drugs gave analgesic activities that were comparable to those of oral delivery 5 – 8 min after administration at doses that were 3 – 5 orders of magnitude lower.

Keywords

nonsteroidal anti-inflammatory drugs nanoaerosols indomethacin butadion diclofenac 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • S. V. An’kov
    • 1
  • T. G. Tolstikova
    • 1
    Email author
  • A. A. Onishchuk
    • 2
    • 5
  • M. V. Khvostov
    • 1
  • I. V. Sorokina
    • 1
  • A. M. Baklanov
    • 2
  • V. M. Fomin
    • 3
  • V. V. Boldyrev
    • 4
    • 5
  1. 1.N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  2. 2.V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  3. 3.S. A. Khristianovich Institute of Theoretical and Applied Mechanics, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  4. 4.Institute of Solid State Chemistry and Mechanochemistry, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  5. 5.Novosibirsk State National Research UniversityNovosibirskRussia

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