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Pharmaceutical Chemistry Journal

, Volume 49, Issue 3, pp 175–177 | Cite as

Synthesis and Antimicrobial Activity of 5-Aryl-4-Acyl-3-Hydroxy-1-[2-(2-Hydroxyethoxy)-Ethyl]-3-Pyrrolin-2-Ones

  • V. L. GeinEmail author
  • T. F. Odegova
  • S. N. Rogachev
  • A. A. Bobyleva
  • L. F. Gein
Article

Interaction of 2-(2-aminoethoxy)ethanol with a mixture of an aromatic aldehyde and the methyl esters of acetylpyruvic acids yielded 5-aryl-4-acyl-3-hydroxy-1-[2-(2-hydroxyethoxy)ethyl]-3-pyrrolin-2-ones. The antimicrobial activity of the compounds synthesized here was studied.

Keywords

5-aryl-4-acyl-3-hydroxy-1-[2-(2-hydroxyethoxy)ethyl]-3-pyrrolin-2-ones synthesis antimicrobial activity 

References

  1. 1.
    V. L. Gein, V. N. Vychegzhanina, E. B. Levandovskaya, et al., Khim.-Farm. Zh., 44(7), 30 – 33 (2010); Pharm. Chem. J., 44(7), 370 – 373 (2010).Google Scholar
  2. 2.
    V. L. Gein, Tetrahydropyrrol- and Tetrahydrofuran-2,3-diones [in Russian], PGFA, Perm (2004).Google Scholar
  3. 3.
    M. D. Mashkovskii, Medicines: A Handbook for Doctors [in Russian], Novaya Volna, Moscow (2005).Google Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • V. L. Gein
    • 1
    Email author
  • T. F. Odegova
    • 1
  • S. N. Rogachev
    • 1
  • A. A. Bobyleva
    • 1
  • L. F. Gein
    • 2
  1. 1.Perm State Pharmaceutical AcademyRussian Ministry of HealthPermRussia
  2. 2.Academician E. A. Vagner Perm State Medical AcademyRussian Ministry of HealthPermRussia

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