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Amperometric Detection of Allopurinol in Flow-Injection Analysis on Electrodes Modified by Carbon Nanotubes and Mixed-Valence Ruthenium and Iridium Oxides

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Pharmaceutical Chemistry Journal Aims and scope

Mixed-valence oxides of ruthenium (RuO x ) and iridium (IrO x ) and a composite based on them (IrO x —RuO x ) exhibited catalytic activity for allopurinol oxidation when electrodeposited on the surfaces of unmodified glassy-carbon electrodes and those modified with functionalized single-walled carbon nanotubes (SWCNT). The greatest catalytic effect was observed on the electrode modified with composite IrO x —RuO x —SWCNT. A flow-injection method for amperometric detection of allopurinol at the modified electrode was developed. The analytical signal was linearly dependent on allopurinol concentration in the range 1 × 10– 6 – 5 ×10−3 M.

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Acknowledgments

The work was supported financially by the Russian Foundation for Basic Research (Grant No. 12-03-97031-r povolzh’e a).

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Authors and Affiliations

  1. A. M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlevskaya St., Kazan, Tatarstan, 420008, Russia

    L. G. Shaidarova, I. A. Chelnokova, G. F. Makhmutova, A. V. Gedmina & G. K. Budnikov

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  1. L. G. Shaidarova
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  2. I. A. Chelnokova
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  3. G. F. Makhmutova
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  4. A. V. Gedmina
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  5. G. K. Budnikov
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Corresponding author

Correspondence to L. G. Shaidarova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 8, pp. 36 – 41, August, 2014.

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Shaidarova, L.G., Chelnokova, I.A., Makhmutova, G.F. et al. Amperometric Detection of Allopurinol in Flow-Injection Analysis on Electrodes Modified by Carbon Nanotubes and Mixed-Valence Ruthenium and Iridium Oxides. Pharm Chem J 48, 537–542 (2014). https://doi.org/10.1007/s11094-014-1146-z

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  • DOI: https://doi.org/10.1007/s11094-014-1146-z

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