Pharmaceutical Chemistry Journal

, Volume 48, Issue 4, pp 231–234 | Cite as

Synthesis and Neurotropic Activity of Triazolo[3,4-a]-and Triazolo[5,1-a][2,7]Naphthyridines

  • S. N. Sirakanyan
  • N. A. Tonoyants
  • A. S. Noravyan
  • I. A. Dzhagatspanyan
  • I. M. Nazaryan
  • A. G. Akopyan
  • R. G. Paronikyan
  • N. S. Minasyan
Article
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Methods for synthesizing new substituted 7,8,9,10-tetrahydro[1,2,4]triazolo[3,4-a][2,7]naphthyridines from -hydrazino-7-isopropyl-3-chloro-5,6,7,8-tetrahydro[2,7]naphthyridine-4-carbonitrile were developed. It was shown that heating triazolo[3,4-a][2,7]-naphthyridines in an excess of amines produced isomeric triazolo[5,1-a][2,7]naphthyridine derivatives. These isomers were interconverted using a Dimroth rearrangement. The neurotropic activity of the synthesized compounds was studied.

Keywords

[2,7]naphthyridines [1,2,4]triazolo[3,4-a][2,7]naphthyridines [1,2,4]triazolo[5,1-a][2,7] naphthyridines Dimroth rearrangement neurotropic activity 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • S. N. Sirakanyan
    • 1
  • N. A. Tonoyants
    • 1
  • A. S. Noravyan
    • 1
  • I. A. Dzhagatspanyan
    • 1
  • I. M. Nazaryan
    • 1
  • A. G. Akopyan
    • 1
  • R. G. Paronikyan
    • 1
  • N. S. Minasyan
    • 2
  1. 1.A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Centre of Organic and Pharmaceutical ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia
  2. 2.Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia

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