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Pharmaceutical Chemistry Journal

, Volume 48, Issue 3, pp 159–162 | Cite as

Synthesis and Chemico-Pharmaceutical Characteristics of a Somatostatin Analog with Antitumor Activity

  • Z. S. Shprakh
  • I. V. Yartseva
  • E. V. Ignat’eva
  • A. P. Smirnova
  • L. P. Sushinina
  • S. V. Ustinkina
  • L. I. Smirnova
  • A. P. Bud’ko
  • N. I. Zimakova
Article

An analog of somatostatin with hormonal and antitumor activity was synthesized. An optimum synthesis method was developed, yielding standard pharmaceutical somatostatin analog substance for preclinical and clinical studies. A quality control method was developed for inclusion in the draft manufacturer’s pharmacopeia monograph for pharmacological somatostatin analog substance.

Keywords

somatostatin (SST) peptide synthesis antitumor activity chemico-pharmaceutical analysis 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Z. S. Shprakh
    • 1
  • I. V. Yartseva
    • 1
  • E. V. Ignat’eva
    • 1
  • A. P. Smirnova
    • 1
  • L. P. Sushinina
    • 1
  • S. V. Ustinkina
    • 1
  • L. I. Smirnova
    • 1
  • A. P. Bud’ko
    • 1
  • N. I. Zimakova
    • 1
  1. 1.N. N. Blokhin Russian Oncological Scientific CenterRussian Academy of Medical SciencesMoscowRussia

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