Advertisement

Pharmaceutical Chemistry Journal

, Volume 47, Issue 6, pp 295–298 | Cite as

Effect of an Inclusion Complex of an Aminomethylated Dihydroquercetin Derivative in Cyclodextrin on Ozone-Induced Oxidation of Fibrinogen

  • V. S. Rogovsky
  • T. M. Arzamasova
  • M. A. Rosenfel’d
  • M. L. Konstantinova
  • V. B. Leonova
  • S. D. Razumovskii
  • A. I. Matyushin
  • N. L. Shimanovskii
  • A. M. Koroteev
  • S. E. Mosyurov
  • M. P. Koroteev
  • T. S. Kukhareva
  • É. E. Nifant’ev
Article

The ability of a water-soluble inclusion complex (KN-14-CD) of an aminomethylated dihydroquercetin derivative (KN-14) in β-cyclodextrin (CD) to inhibit ozone-induced oxidation of fibrinogen was evaluated. KN-14-CD prevented ozone-induced oxidation of fibrinogen and preserved its ability to form clots after the addition of thrombin. The ability of KN-14-CD to prevent oxidative modification of fibrinogen was more pronounced than that of native dihydroquercetin (taxifolin).

Keywords

KN-14-CD taxifolin cyclodextrin dihydroquercetin oxidative damage of fibrinogen ozone-induced oxidation 

References

  1. 1.
    M. V. Karlina, O. N. Pozharitskaya, and A. N. Shikov, Khim.-farm. Zh., 43(6), 46 – 48 (2009).Google Scholar
  2. 2.
    V. S. Rogovskii, N. L. Shimanovskii, and A. I. Matyushin, Eksp. Klin. Farmakol., 75(9), 37 – 41 (2012).PubMedGoogle Scholar
  3. 3.
    E. B. Meh’shchikova, V. Z. Lankin, N. K. Zenkov, et al., Oxidative Stress. Pro-oxidants and Antioxidants [in Russian], Firma Slovo, Moscow (2006).Google Scholar
  4. 4.
    V. A. Kurkin, V. M. Ryzhov, O. V. Biryukova, et al., Khim.-farm. Zh., 43(2), 33 – 42 (2009).Google Scholar
  5. 5.
    V. S. Rogovsky, M. A. Rosenfeld, V. B. Leonova, et al., J. Information, Intelligence Knowledge, 4(1), 53 – 60 (2012).Google Scholar
  6. 6.
    I. P. Ivanova, D. I. Knyazev, and Yu. V. Kudryavtsev, Sovrem. Tekhnol. Med., No. 3, 16 – 20 (2011).Google Scholar
  7. 7.
    K. B. Pandey, N. Mishra, and S. I. Rizvi, Clin. Biochem., No. 43, 508 – 511 (2010).Google Scholar
  8. 8.
    C. Banfi, M. Brioschi, S. Barcella, et al., Eur. J. Heart Failure, 10, 244 – 251 (2008).CrossRefGoogle Scholar
  9. 9.
    M. A. Rozenfel’d, V. B. Leonova, M. L. Konstantinova, and S. D. Razumovskii, Izv. Ross. Akad. Nauk, Ser. Biol., No. 6, 671 – 679 (2008).Google Scholar
  10. 10.
    L. C. Dijkgraaf, G. Zaardeneta, F. W. Corddewener, et al., J. Oral Maxillofac. Surg., No. 61, 101 – 111 (2003).Google Scholar
  11. 11.
    E. Shacter, J. A. Williams, and R. F. Levine, Free Radical Biol. Med., No. 18, 815 – 831 (1995).Google Scholar
  12. 12.
    M. A. Belisario, D. Domenico, C. Pelagalli, et al., Biochimie, No. 79, 449 – 455 (1997).Google Scholar
  13. 13.
    E. V. Roitman, O. A. Azizova, Yu. A. Morozov, and A. V. Aseichev, Byull. Eksp. Biol. Med., No. 138, 527 – 530 (2004).Google Scholar
  14. 14.
    M. A. Rozenfel’d, V. B. Leonova, A. N. Shchegolikhin, et al., Biokhimiya, 75(10), 1451 – 1461 (2010).Google Scholar
  15. 15.
    O. A. Azizova, E. V. Maksyanina, Yu. A. Romanov, et al., Byull. Eksp. Biol. Med., No. 137, 406 – 409 (2004).Google Scholar
  16. 16.
    V. I. Lushchak, Biokhimiya, No. 72, 995 – 1017 (2007).Google Scholar
  17. 17.
    O. A. Azizova, A. V. Aseichev, A. P. Piryazev, and L. V. Shulenina, Byull. Eksp. Biol. Med., No. 3, 284 – 290 (2009).Google Scholar
  18. 18.
    RU Pat. 2,396,077 (2009), Aug. 10, 2010; Ref. Zh. Khim., A61P9 / 14 (2009).Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • V. S. Rogovsky
    • 1
  • T. M. Arzamasova
    • 1
  • M. A. Rosenfel’d
    • 2
  • M. L. Konstantinova
    • 2
  • V. B. Leonova
    • 2
  • S. D. Razumovskii
    • 2
  • A. I. Matyushin
    • 1
  • N. L. Shimanovskii
    • 1
  • A. M. Koroteev
    • 3
  • S. E. Mosyurov
    • 3
  • M. P. Koroteev
    • 3
  • T. S. Kukhareva
    • 3
  • É. E. Nifant’ev
    • 3
  1. 1.Department of Molecular Pharmacology and Radiobiology, Medico-Biological FacultyPirogov State Research Medical UniversityMoscowRussia
  2. 2.Emanuel Institute of Biochemical PhysicsRussian Academy of SciencesMoscowRussia
  3. 3.Department of Organic ChemistryMoscow State Pedigogical UniversityMoscowRussia

Personalised recommendations