Pharmaceutical Chemistry Journal

, Volume 47, Issue 4, pp 219–224 | Cite as

Evaluating the Stability of a Cationic Plastoquinone Derivative (PDTP) in Visomitin Eye Drops

  • D. A. Tsarev
  • R. S. Zverev
  • E. M. Kazmina
  • V. N. Tashlitsky
  • V. P. Skulachev
Article

The stability of plastoquinonyldecyltriphenylphosphonium bromide (PDTP) in Visomitin eye drops was evaluated. The shelf life of these drops stored in a refrigerator and at room temperature and after opening the packaging was established. The importance of using light-protective secondary packaging was demonstrated.

Keywords

visomitin stability eye drops PDTP 

References

  1. 1.
    V. P. Skulachev, Biokhimiya, 72, 1700 – 1714 (2007).Google Scholar
  2. 2.
    V. M. Skulachev, Y. N. Antonenko, V. N. Anisimov, et al., Curr. Drug Targets, 12(6), 800 – 826 (2011).PubMedCrossRefGoogle Scholar
  3. 3.
    E. V. Yani, L. A. Katargina, N. B. Chesnokova, et al., Prakticheskaya Meditsina, 04 (12); Oftal’mologiya, 1, 134 – 137 (2012).Google Scholar
  4. 4.
    L. T. Arkhipova, M. M. Arkhipova, L. E. Bakeeva, et al., Biokhimiya, 73(12), 1641 – 1654 (2008).Google Scholar
  5. 5.
    V. B. Saprunova, D. I. Pilipenko, A. V. Alekseevskii, et al., Biokhimiya, 75(2), 158 – 168 (2010).Google Scholar
  6. 6.
    N. A. Stefanova, A. Zh. Fursova, N. G. Kolosova, J. Alzheimer’s Dis., 21(2), 479 – 491 (2010).Google Scholar
  7. 7.
    A. M. Markovets, A. Z. Fursova, N. G. Kolosova, PLoS One, 6(7), 5 (2011).CrossRefGoogle Scholar
  8. 8.
    E. N. Grigoryan, Y. P. Novikova, O. S. Gancharova, et al., Adv. Aging Res., 1(2), 31 – 37 (2012).CrossRefGoogle Scholar
  9. 9.
    K. C. Waterman, R. C. Adami, Int. J. Pharm., 293, 101 – 125 (2005).PubMedCrossRefGoogle Scholar
  10. 10.
    A. A. Matyushin, D. A. Tsarev, M. A. Grigorenko, et al., Farmatsiya, 5, 23 – 29 (2008).Google Scholar
  11. 11.
    Table of Typical Illuminances. URL: http://broyhill.edublogs.org/2009/08/09/lux (accessed Oct. 17, 2012).

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • D. A. Tsarev
    • 2
    • 5
  • R. S. Zverev
    • 4
  • E. M. Kazmina
    • 3
  • V. N. Tashlitsky
    • 2
    • 5
  • V. P. Skulachev
    • 1
  1. 1.Chemistry Department, Moscow State UniversityMoscowRussia
  2. 2.Pharmacology Department, Sechenov First Moscow State Medical UniversityMoscowRussia
  3. 3.MITOTECH Ltd.MoscowRussia
  4. 4.Institute of Mitoengineering, Moscow State UniversityMoscowRussia
  5. 5.Belozersky Institute of Physicochemical Biology, Moscow State UniversityMoscowRussia

Personalised recommendations