Pharmaceutical Chemistry Journal

, Volume 46, Issue 9, pp 551–552 | Cite as

Synthesis and analgesic activity of 1-aryl-3-aroyl-4-hydroxy-5',5'-dimethyl-8',9'-diethoxy-5',6'-dihydro-3'h-spiro{pyrrole-2,2'-pyrrolo[2,1-a]isoquinoline}-3',5(1H )-diones

  • E. S. Denislamova
  • Yu. V. Shklyaev
  • R. R. Makhmudov
  • A. N. Maslivets
Article
First Online:
Received:

1-Aryl-4-aroyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones reacted with 6,7-diethoxy-1,3,3-trimethyl-3,4-dihydroisoquinoline with the formation of 1-aryl-3-aroyl-4-hydroxy-5',5'-dimethyl-8',9'-diethoxy-5',6'-dihydro-3'H-spiro{pyrrole-2,2'-pyrrolo[2,1-a]isoquinoline}-3',5(1H)-diones. The synthesized compounds exhibited analgesic activity.

Keywords

1H-pyrrole-2,3-diones 1-methyl-3,4-dihydroisoquinolines analgesic activity 
This is a preview of subscription content, log in to check access.

Notes

Acknowledgments

The work was supported financially by the RF Ministry for Education and Science (Project 2.19.10).

References

  1. 1.
    Yu. N. Bannikova, A. N. Maslivets, and Z. G. Aliev, Zh. Org. Khim., 43, 1339 – 1342 (2007).Google Scholar
  2. 2.
    E. S. Denislamova and A. N. Maslivets, Zh. Org. Khim., 46, 396 – 400 (2010).Google Scholar
  3. 3.
    Yu. V. Shklyaev and A. N. Maslivets, Zh. Org. Khim., 32, 319 (1996).Google Scholar
  4. 4.
    Yu. N. Bannikova, Yu. S. Rozhkova, Yu. V. Shklyaev, and A. N. Maslivets, Zh. Org. Khim., 44, 706 – 709 (2008).Google Scholar
  5. 5.
    N. B. Eddy and D. Leimbach, J. Pharmacol. Exp. Ther., 107, 385 – 395 (1953).PubMedGoogle Scholar
  6. 6.
    L. Belen’kii, Elements of Quantitative Estimation of the Pharmacological Effect [in Russian], Meditsinskaya Literatura, Leningrad (1963).Google Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • E. S. Denislamova
    • 1
    • 3
  • Yu. V. Shklyaev
    • 2
  • R. R. Makhmudov
    • 1
  • A. N. Maslivets
    • 1
    • 3
  1. 1.Institute of Natural SciencesPerm State UniversityPermRussia
  2. 2.Institute of Technical Chemistry, Ural BranchRussian Academy of SciencesPermRussia
  3. 3.Perm State UniversityPermRussia

Personalised recommendations