Pharmaceutical Chemistry Journal

, Volume 46, Issue 9, pp 531–535 | Cite as

Synthesis and antitumor activity of 2-N- and 3-S-substituted 5-[2-(4-)benzyloxyphenyl]-1,2,4-triazoles and acylhydrazides

  • L. A. Grigoryan
  • M. A. Kaldrikyan
  • R. G. Melik-Ogandzhanyan
  • F. G. Arsenyan
Article
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3-Thio-4-phenyl-5-[2-(4-)benzyloxyphenyl]-1,2,4-triazoles were prepared by cyclization of the corresponding thiosemicarbazides in alkaline medium. The 2-N-substituted derivatives of the aforementioned triazoles were obtained via aminomethylation, cyanethylation, and alkylation of α-epoxides. 3-S-Substituted 1,2,4-triazoles were synthesized by alkylation with various aliphatic and aromatic halides. Acylhydrazides were prepared via reaction of 2-(4-)benzyloxybenzoic acid hydrazides with dicarboxylic acid anhydrides. The antitumor activity of the synthesized compounds was studied.

Key words

hydrazide thiosemicarbazide triazole aminomethylation cyanethylation alkylation α-epoxide acylhydrazide antitumor activity 
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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • L. A. Grigoryan
    • 1
  • M. A. Kaldrikyan
    • 1
  • R. G. Melik-Ogandzhanyan
    • 1
  • F. G. Arsenyan
    • 1
  1. 1.Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia

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