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Pharmaceutical Chemistry Journal

, Volume 46, Issue 9, pp 526–530 | Cite as

Synthesis and pharmacological activity of 3-(n,n-disubstituted)acetamide-1-r-2-aminobenzimidazolium chlorides

  • V. A. Anisimova
  • A. A. Spasov
  • V. A. Kosolapov
  • I. E. Tolpygin
  • L. V. El’tsova
  • A. F. Kucheryavenko
  • L. V. Naumenko
  • N. A. Gurova
  • K. V. Lenskaya
  • D. S. Yakovlev
  • D. V. Mal’tsev
  • T. M. Mitina
  • O. Yu. Grechko
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A series of 3-(N,N-disubstituted)acetamide-1-R-2-aminobenzimidazolium chlorides were synthesized. Their pharmacological properties were studied. It was established that the synthesized substances decreased platelet aggregation and possessed antioxidant and antiarrhythmic activity. Some of the compounds produced a hypoglycemic action and exhibited antagonistic activity with respect to serotonin 5-HT2 receptors.

Keywords

synthesis acetamides 2-aminobenzimidazoles antiaggregant activity antiarrhythmic action 5-HT2-antagonist activity hypoglycemic properties antioxidant action 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • V. A. Anisimova
    • 1
  • A. A. Spasov
    • 2
    • 3
    • 4
  • V. A. Kosolapov
    • 2
    • 3
  • I. E. Tolpygin
    • 1
  • L. V. El’tsova
    • 3
  • A. F. Kucheryavenko
    • 2
  • L. V. Naumenko
    • 3
  • N. A. Gurova
    • 2
  • K. V. Lenskaya
    • 2
  • D. S. Yakovlev
    • 2
    • 4
  • D. V. Mal’tsev
    • 2
  • T. M. Mitina
    • 2
  • O. Yu. Grechko
    • 2
  1. 1.Research Institute of Physical and Organic ChemistrySouthern Federal UniversityRostov-on-DonRussia
  2. 2.Volgagrad State Medical UniversityVolgogradRussia
  3. 3.Research Institute of PharmacologyVolgograd State Medical UniversityVolgogradRussia
  4. 4.Volgograd Medical Scientific CenterVolgogradRussia

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