Pharmaceutical Chemistry Journal

, Volume 46, Issue 8, pp 478–481 | Cite as

Synthesis and molecular-weight characteristics of n-vinylpyrrolidone and 2-methyl-5-vinylpyridine copolymers

  • S. A. Kedik
  • A. V. Panov
  • I. V. Sakaeva
  • Yu. V. Kochkina(Cherta)
  • D. V. Eremin
  • V. V. Suslov
Article
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N-Vinylpyrrolidone and 2-methyl-5-vinylpyridine copolymers with various ratios of monomer units and molecular weights were synthesized by radical copolymerization using an injection method. The ratio of monomer units was determined by non-aqueous potentiometric titration and 13C NMR methods. The viscosity-average molecular weights of copolymers containing 35 – 39 mol% of 2-methyl-5-vinylpyridine were in the range 15.2 – 27.6 kDa. Copolymers with 2-methyl-5-vinylpyridine content up to 75 ± 5 mol% exhibited good solubility in water.

Key words

copolymer synthesis N-vinylpyrrolidone 2-methyl-5-vinylpyridine 
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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • S. A. Kedik
    • 1
  • A. V. Panov
    • 1
  • I. V. Sakaeva
    • 2
  • Yu. V. Kochkina(Cherta)
    • 2
  • D. V. Eremin
    • 1
  • V. V. Suslov
    • 1
  1. 1.Institute of Pharmaceutical TechnologyMoscowRussia
  2. 2.State Scientific Center for Drug Expertise and Control, Ministry of Public Health of the Russian FederationMoscowRussia

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