Antioxidant, analgesic and anti-inflammatory properties of new ninhydrin adduct of embelin
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Based on a reaction of ninhydrin with phenols, a new embelin-ninhydrin adduct has been synthesized and characterized. The adduct exhibits high antioxidant activity in the DPPH test. The analgesic and anti-inflammatory activity was also found to be better than that of the parent compound (embelin). In the acetic-acid-induced writhing test, almost complete abolition of writhing was observed at 10 and 20 mg/(kg body weight) doses of embelin-ninhydrin adduct and the results were better than those achieved with the standard drug pentazocine.
KeywordsEmbelin, ninhydrin free radicals, analgesic, carrageenan
One of the authors (S. M.) would like to thank the University Grants Commission (New Delhi) for awarding a Junior Research Fellowship. The authors are grateful to the NMR Research Centre at the Indian Institute of Science (Bangalore) for providing NMR data.
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