Synthesis and antitumor activity of a series of benzofuryl-substituted 1,2,4-triazoles and triazolin-5-thiones

3-Benzofuryl-4-benzyl(cyclohexyl)-5-mercapto-1,2,4-triazoles were synthesized by cyclization of the corresponding substituted thiosemicarbazides. 5-Mercaptotriazoles were S-alkylated with various alkenyl-substituted benzylhalogenides, chloracetamide, chloroacetic, and α-bromopropionic and α-bromocaproic acids. The aminomethylation and hydroxymethylation reactions of 3-benzofuryl-4-benzyl(cyclohexyl)-5-mercapto-1,2,4-triazoles were studied. The antitumor activity of the resulting compounds was investigated.