Pharmaceutical Chemistry Journal

, Volume 44, Issue 9, pp 480–482 | Cite as

Synthesis, analgesic and anti-inflammatory activity of (1Z,3Z)-4-aryl-4-hydroxy-1-(3,3-dialkyl-3,4-dihydroisoquinoline-1(2H)-ylidene)-but-3-en-4-ones

  • V. V. Khalturina
  • Yu. V. Shklyaev
  • R. R. Makhmudov
  • A. N. Maslivets
Article
First Online:
Received:

It is established that 6-aryl-2,2-dimethyl-4H-1,3-dioxin-4-ones react with 3,3-dialkyl-1-methyl-3,4-dihydroisoquinolines with the formation of (1Z,3Z)-4-aryl-4-hydroxy-1-(3,3-dialkyl-3,4-dihydroisoquinoline1(2H)-ylidene)-but-3-en-4-ones. The synthesized compounds were tested for anti-inflammatory and analgesic properties.

Key words

dioxinones 1-methyl-3,4-dihydroisoquinolines analgesic activity anti-inflammatory activity 
This is a preview of subscription content, log in to check access.

Notes

Acknowledgments

The work was performed with financial support of the Russian Foundation for Basic Research (Grant No. 08-03-01032).

References

  1. 1.
    V. V. Khalturina, Yu. V. Shklyaev, Z. G. Aliev, et al., Zh. Org. Khim., 5, 743 (2009).Google Scholar
  2. 2.
    N. B. Eddy and D. Leimbach, J. Pharmacol. Exp. Ther., 107, 385 – 393 (1953).PubMedGoogle Scholar
  3. 3.
    Methodical recommendations for experimental pre-clinical tests of non-steroidal anti-inflammatory drugs, Moscow (1982). Approved by the Pharmacology Committee, Min. Health USSR, Nov. 11, 1992. Protocol No. 22.Google Scholar
  4. 4.
    L. Belen?kii, Quantitative Evaluation of the Pharmacological Effect [in Russian], Meditsinskaya Literatura, Leningrad (1963).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • V. V. Khalturina
    • 1
  • Yu. V. Shklyaev
    • 1
  • R. R. Makhmudov
    • 2
  • A. N. Maslivets
    • 2
  1. 1.Institute of Technical Chemistry, Ural BranchRussian Academy of SciencesPermRussia
  2. 2.Institute of Natural SciencesPerm State UniversityPermRussia

Personalised recommendations