Pharmaceutical Chemistry Journal

, Volume 44, Issue 7, pp 360–365 | Cite as

Targeted search for a lead compound in a series of cinnamic acid derivatives possessing antiradical activity

  • V. S. Agadzhanyan
  • E. T. Oganesyan
  • V. T. Abaev
Article
  • 119 Downloads

Indices of reactivity with respect to active oxygen species that resulted from quantum-chemical calculations (PM3 and AM1) have been studied in a series of hydroxyl-and methoxy-derivatives of cinnamic acid. The high antioxidant activity of 4-hydroxy-3,5-di-tert-butylcinnamic acid has been predicted and then experimentally confirmed, which can be of interest for the creation of new drugs.

Key words

cinnamic acid derivatives sterically hindered phenols chemical structure—activity relationship 

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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • V. S. Agadzhanyan
    • 1
  • E. T. Oganesyan
    • 1
  • V. T. Abaev
    • 2
  1. 1.Pyatigorsk State Pharmaceutical AcademyPyatigorskRussia
  2. 2.North-Ossetian State UniversityVladikavkazRussia

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