Pharmaceutical Chemistry Journal

, Volume 44, Issue 7, pp 360–365 | Cite as

Targeted search for a lead compound in a series of cinnamic acid derivatives possessing antiradical activity

  • V. S. Agadzhanyan
  • E. T. Oganesyan
  • V. T. Abaev

Indices of reactivity with respect to active oxygen species that resulted from quantum-chemical calculations (PM3 and AM1) have been studied in a series of hydroxyl-and methoxy-derivatives of cinnamic acid. The high antioxidant activity of 4-hydroxy-3,5-di-tert-butylcinnamic acid has been predicted and then experimentally confirmed, which can be of interest for the creation of new drugs.

Key words

cinnamic acid derivatives sterically hindered phenols chemical structure—activity relationship 


  1. 1.
    V. S. Agadzhanyan and E. T. Oganesyan, Khim.-farm. Zh., 42(11), 12–17 (2008).Google Scholar
  2. 2.
    V. Agadjanyan and E. Oganesyan, in: Fourth Intern. Symp. On Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI 2007), Moscow (2007), p. 72.Google Scholar
  3. 3.
    M. D. Mashkovskii, Drugs [in Russian], Novaya Volna, Moscow (2000).Google Scholar
  4. 4.
    L. S. Vartanyan and S. M. Gurevich, Vopr. Med. Khim., 45(4), 8–16 (1999).Google Scholar
  5. 5.
    V. B. Vol?eva, I. S. Belostotskaya, N. L. Komisarova, et al., Zh. Org. Khim., 43(10), 1495–1498 (2007).Google Scholar
  6. 6.
    I. S. Belostotskaya, V. B. Vol?eva, N. L. Komisarova, et al., Zh. Org. Khim., 44(6), 814–817 (2008).Google Scholar
  7. 7.
    A. A. Avanesyan, A. N. Pashkov, N. A. Simonyan, et al., Khim.-farm. Zh., 43(5), 18–19 (2009).Google Scholar
  8. 8.
    A. V. Sadym, A. A. Lagunin, D. A. Filimonov, and V. V. Poroikov, Khim.-farm. Zh., 36(10), 21–26 (2002).Google Scholar
  9. 9.
    D. A. Filimonov and V. V. Poroikov, Ross. Khim. Zh., 50(2), 66–75 (2006).Google Scholar
  10. 10.
    E. T. Oganesyan, Khim.-farm. Zh., 20(6), 696–702 (1986).Google Scholar
  11. 11.
    T. V. Sirota, Vopr. Med. Khim., 45(3), 23–34 (1999).Google Scholar
  12. 12.
    R. M. C. Dawson, D. C. Elliott, W. H. Elliott, and K. M. Jones, eds., Data for Biochemical Research, Clarendon Press, Oxford (1986).Google Scholar
  13. 13.
    E. T. Oganesyan, E. G. Dorkina, M. R. Khochava, et al., Khim.-farm. Zh., 36(12), 21–25 (2002).Google Scholar
  14. 14.
    E. T. Oganesyan, Yu. A. Mal?tsev, and D. E. Tvorovskii, Zh. Obshch. Khim. 71(6), 999–1005 (2001).Google Scholar
  15. 15.
    K. K. Timergazin and S. L. Khursan, Izv. Akad. Nauk, Ser. Khim., No. 12, 2858–2861 (1996).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • V. S. Agadzhanyan
    • 1
  • E. T. Oganesyan
    • 1
  • V. T. Abaev
    • 2
  1. 1.Pyatigorsk State Pharmaceutical AcademyPyatigorskRussia
  2. 2.North-Ossetian State UniversityVladikavkazRussia

Personalised recommendations