Synthesis and antibacterial activity of some new 1-aroyl-3-(substituted-2-benzothiazolyl)thioureas

  • Aamer Saeed
  • Hummera Rafique
  • A. Hameed
  • S. Rasheed
Article

Abstract

An efficient, synthesis of some new 1-aroyl-3-(substituted-2-benzothiazolyl)-thioureas is reported. Substituted anilines were treated with potassium thiocyanate and bromine in acidic medium to afford the corresponding 2-amino-benzothiazoles (2a–e). Treatment of the latter with suitably substituted aroyl isocyanates, produced in situ by reaction of corresponding aroyl chlorides with thiocyanate in acetone, afforded the 1-aroyl-3-(substituted-2-benzothiazolyl)thioureas (3a–k). The structures were confirmed by physical, IR, NMR, and mass spectral data. The synthesized compounds (2a–d, 3a–k) were assayed in vitro for their antimicrobial activity against Gram positive and Gram negative bacteria and were found to exhibit moderate to potent activity towards the tested microorganisms, as compared to the standard drugs.

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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • Aamer Saeed
    • 1
  • Hummera Rafique
    • 1
  • A. Hameed
    • 2
  • S. Rasheed
    • 2
  1. 1.Department of ChemistryQuaid-I-Azam UniversityIslamabadPakistan
  2. 2.Department of MicrobiologyQuaid-I-Azam UniversityIslamabadPakistan

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