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Pharmaceutical Chemistry Journal

, Volume 42, Issue 4, pp 157–164 | Cite as

Magnetohydrodynamic thermochemotherapy of malignant tumors with nanopreparations with magnetic resonance monitoring

  • N. A. Brusentsov
  • T. N. Brusentsova
  • E. Yu. Filinova
  • Yu. A. Pirogov
  • D. A. Kupriyanov
  • A. I. Dubina
  • M. N. Shumskikh
  • L. I. Shumakov
  • N. Ya. Yurchenko
  • E. A. Anashkina
  • A. A. Shevelev
Molecular-Biological Problems of Drug Design and Mechanisms of Drug Action

Abstract

Intravenous administration of dextran-ferrite sol was used to amplify T2-weighed echo gradient (500/15) scanning MR images with visualization of the invasion margins of tumor cells into healthy tissues, along with macro-and micrometastases, in animals with lymphocytic leukemia and Ehrlich and Lewis carcinomas. Magnetohydrodynamic thermochemotherapy (MTCT) using a cyclophosphamide-containing magnetic fluid (saturation magnetization (Ms) 8.6 kA/m, pH 7.4, ζ + 13 mV) at 46°C for 30 min in an alternating magnetic field (0.88 MHz, 7.2 kA/m, 0.15 kW) with aspiration of necrotic material (ANM) produced regression of P388 tumors of volume ∼110 mm3 in BDF1 mice prior to metastasis by 40%, with an increase in lifetime (ILT) of 310%; in tumors of volume ∼330 mm3 after metastasis and MTCT-ANM with cyclophosphamide pretreatment, ILT was 220%.

Keywords

Magnetic Fluid Lewis Lung Carcinoma Intratumor Injection Magnetic Tomography Alternate Magnetic Field 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • N. A. Brusentsov
    • 1
    • 2
  • T. N. Brusentsova
    • 1
  • E. Yu. Filinova
    • 3
  • Yu. A. Pirogov
    • 4
  • D. A. Kupriyanov
    • 4
  • A. I. Dubina
    • 4
  • M. N. Shumskikh
    • 4
  • L. I. Shumakov
    • 5
  • N. Ya. Yurchenko
    • 1
  • E. A. Anashkina
    • 1
  • A. A. Shevelev
    • 1
  1. 1.N. N. Blokhin Russian Oncological Scientific CenterRussian Academy of Medical SciencesMoscowRussia
  2. 2.Institute of MechanicsMoscow State UniversityMoscowRussia
  3. 3.Non-Commercial Organization “Progressive Medical Investigations”MoscowRussia
  4. 4.Magnetic Tomography and Spectroscopy CenterM. V. Lomonosov Moscow State UniversityMoscowRussia
  5. 5.All-Russian Science Research Institute of RadiotechnologiesMoscowRussia

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