Pharmaceutical Chemistry Journal

, Volume 42, Issue 1, pp 15–17 | Cite as

Pharmacological activity of 16-and 18-member dibenzodioxatetraaza macroheterocyclic compounds

  • O. V. Kulikov
  • T. L. Karaseva
  • T. A. Kabanova
  • E. A. Kostenko
  • V. E. Kuz’min
  • S. A. Andronati
Article
  • 25 Downloads

Abstract

The spectrum of the biological activities (within the framework of the PASS program) that 16-and 18-member dibenzodioxatetraaza macroheterocyclic compounds might have is assessed. compounds of these classes were found to have anticonvulsant activity. 16-Member macrocyclic compounds could have antiaggregatory activity. These results lead to the conclusion that antiaggregatory and anticonvulsant substances may be found among similar macroheterocyclic compounds.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    O. V. Kulikov, V. I. Pavlovskii, and S. A. Andronati, Khim. Geterots. Soedin., No. 12, 1763–1795 (2005).Google Scholar
  2. 2.
    S. A. Andronati, Yu. A. Simonov, V. I. Pavlovskii, et al., Zh. Obshch. Khim, 75(6), 969–977 (2005).Google Scholar
  3. 3.
    O. V. Kulikov, S. A. Andronati, V. I. Pavlovskii, et al., Vis. Odes. Nats. Universitetu Ser. Khimiya, 5(2), 68–76 (2000).Google Scholar
  4. 4.
    Yu. A. Simonov, K. Suvinska, V. I. Pavlovskii, et al., Dop. NAN Ukr., No. 6, 140–146 (2001).Google Scholar
  5. 5.
    O. V. Kulikov, V. I. Pavlovskii, A. V. Mazepa, and S. A. Andronati, Khim. Geterots. Soedin., No. 4, 566–573 (2003).Google Scholar
  6. 6.
    V. I. Pavlovskii, O. V. Kulikov, N. V. Rusakova, et al., Izv. Akad. Nauk., Ser. Khim., No. 4, 755–758 (2004).Google Scholar
  7. 7.
    N. V. Rusakova, V. I. Pavlovskii, O. V. Kulikov, et al., Zh. Neorg. Khim, 50, No. 10, 1627–1631 (2005).Google Scholar
  8. 8.
    A. V. Sadym, A. A. Lagunin, D. A. Filimonov, and V. V. Poroikov, Khim.-Farm. Zh., 36, No. 10, 21–26 (2002).Google Scholar
  9. 9.
    A. V. Kuz’mina, Thesis for Doctorate in Chemical Sciences, Odessa (1988).Google Scholar
  10. 10.
    R. B. Badzhpai, Thesis for Doctorate in Chemical Sciences, Odessa (1986).Google Scholar
  11. 11.
    N. Ya. Golovenko, T. L. Karaseva, and Z. I. Zhilina, Khim.-Farm. Zh., 13, No. 8, 62–68 (1979).Google Scholar
  12. 12.
    V. I. Pavlovskii, O. V. Kulikov, T. L. Karaseva, et al., Ukr. Khim. Zh., 64, No. 12, 123–128 (1998).Google Scholar
  13. 13.
    S. A. Andronati, G. Ya. Avrutskii, A. V. Bogatskii, et al., Phenazepam [in Russian], Naukova Dumka, Kiev (1982), pp. 145–151.Google Scholar
  14. 14.
    G. V. R. Born, Nature, 194(4832), 927–929 (1962).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • O. V. Kulikov
    • 1
  • T. L. Karaseva
    • 1
  • T. A. Kabanova
    • 1
  • E. A. Kostenko
    • 1
  • V. E. Kuz’min
    • 1
  • S. A. Andronati
    • 1
  1. 1.A. V. Bogatskii Physicochemical InstituteUkrainian National Academy of SciencesOdessaUkraine

Personalised recommendations