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Pharmaceutical Chemistry Journal

, Volume 41, Issue 12, pp 670–675 | Cite as

Quality control of teraphthal production. 1. Chemical composition

  • M. S. Goizman
  • E. V. Degterev
  • K. F. Turchin
  • A. P. Arzamastsev
Article

Abstract

It is shown that the drug teraphthal should be considered as a mixture of the octasodium salt of cobalt(II) 2,3,9,10,16,17,23,24-octacarboxyphthalocyanine (OCPC) and its oxidation product (component A) with the octasodium salt of OCPC and products from the extensive destruction of a substance with a similar elemental composition (component B). The composition can be estimated quantitatively using (i) the results of elemental analysis (H, N, Co) and (ii) PMR in combination with measurement of the weight loss on drying.

Keywords

Cobalt Phthalocyanine Proton Magnetic Resonance Spectrum Broad Resonance Component Composition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    State Standard of Quality. Manufacturer's Pharmacopoeic Article MPA 42-0047-1680-01 “Teraphthal.”Google Scholar
  2. 2.
    J. Houben and T. Weyl, Methoden der organische Chemie, Vol. 4, Halogenverbindungen, 4th Ed., G. Thieme Verlag, Stuttgart (1960).Google Scholar
  3. 3.
    L. Pauling, The Nature of the Chemical Bond and the Structure of Molecules and Crystals, Cornell Univ. Press, Ithaca (1939).Google Scholar
  4. 4.
    State Pharmacopoeia, XI Ed., Nos. 1 and 2, Moscow (1998).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • M. S. Goizman
    • 1
  • E. V. Degterev
    • 2
  • K. F. Turchin
    • 2
  • A. P. Arzamastsev
    • 3
  1. 1.Research Institute of Organic Intermediates and DyesState Scientific Center of the Russian FederationMoscowRussia
  2. 2.Center for Drug ChemistryAll-Russia Research Institute of Pharmaceutical ChemistryMoscowRussia
  3. 3.Sechenov Medical AcademyMoscowRussia

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