Pharmaceutical Chemistry Journal

, Volume 41, Issue 5, pp 253–255 | Cite as

Synthesis and antibacterial activity of 4-(1-naphthyl)-6-arylpyrimidin-2-(1H)-ones

  • K. Vijayaramalingam
  • S. Chandrasekaran
  • S. Nagarajan
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A series of new 4-(1-naphthyl)-6-arylpyrimidin-2-(1H)-ones has been synthesized directly from 2-amino-4-(1-naphthyl)-6-arylpyrimidines by nitrosation reaction and also from 1-(1-naphthyl)-3-arylprop-2-en-1-ones in an alcohol solution of urea containing sodium ethoxide. The synthesized compounds were characterized by various spectroscopic methods. All substances showed significant antimicrobial activity in vitro against several standard strains.


Ethanone Sodium Ethoxide Significant Antimicrobial Activity Acetic Acid Medium Dihydropyrimidinone 
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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • K. Vijayaramalingam
    • 1
  • S. Chandrasekaran
    • 1
  • S. Nagarajan
    • 1
  1. 1.Department of ChemistryAnnamalai UniversityAnnamalainagar, Tamil NaduIndia

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