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Pharmaceutical Chemistry Journal

, Volume 41, Issue 1, pp 10–13 | Cite as

Therapeutic effect of phenolic compounds isolated from Rhododendron ungernii leaves

  • E. P. Kemertelidze
  • K. G. Shalashvili
  • B. M. Korsantiya
  • N. O. Nizharadze
  • N. Sh. Chipashvili
Medicinal Plants

Abstract

The sum of phenolic compounds was obtained from the leaves of Caucasian endemic plant Rhododendron ungernii (Trautv.) in the amount of 7%. The extract contains flavonoids, catechins, and anthocyanidins, in particular, quercetin, isoquercetin, quercitrin, hyperin, rutin, (+)-catechin, (−)-epicatechin, (+)-gallocatechin, and leucoanthocyanidins. The sum of phenolic compounds from Rhododendron ungernii completely inhibits Herpes simplex virus reproduction in a bioassay. A new medicinal preparation (Rhodopes) in the form of a 5% ointment was created on the basis of this extract and tested under clinical conditions at a dental clinic and three other specialized medical departments. The results showed a high therapeutic efficacy: Rhodopes favorably influenced the state of patients and caused neither mucosa irritation nor allergic and other adverse reactions. Rhodopes has received State Registration and is recommended for the treatment of all forms of herpetic disorders.

Keywords

Phenolic Compound Quercetin Catechin Rutin Zovirax 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • E. P. Kemertelidze
    • 1
  • K. G. Shalashvili
    • 1
  • B. M. Korsantiya
    • 2
  • N. O. Nizharadze
    • 2
  • N. Sh. Chipashvili
    • 2
  1. 1.Kutateladze Institute of Pharmaceutical ChemistryAcademy of Sciences of GeorgiaTbilisiRepublic of Georgia
  2. 2.Tbilisi State Medical UniversityTbilisiRepublic of Georgia

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