Pharmaceutical Chemistry Journal

, Volume 41, Issue 1, pp 10–13 | Cite as

Therapeutic effect of phenolic compounds isolated from Rhododendron ungernii leaves

  • E. P. Kemertelidze
  • K. G. Shalashvili
  • B. M. Korsantiya
  • N. O. Nizharadze
  • N. Sh. Chipashvili
Medicinal Plants


The sum of phenolic compounds was obtained from the leaves of Caucasian endemic plant Rhododendron ungernii (Trautv.) in the amount of 7%. The extract contains flavonoids, catechins, and anthocyanidins, in particular, quercetin, isoquercetin, quercitrin, hyperin, rutin, (+)-catechin, (−)-epicatechin, (+)-gallocatechin, and leucoanthocyanidins. The sum of phenolic compounds from Rhododendron ungernii completely inhibits Herpes simplex virus reproduction in a bioassay. A new medicinal preparation (Rhodopes) in the form of a 5% ointment was created on the basis of this extract and tested under clinical conditions at a dental clinic and three other specialized medical departments. The results showed a high therapeutic efficacy: Rhodopes favorably influenced the state of patients and caused neither mucosa irritation nor allergic and other adverse reactions. Rhodopes has received State Registration and is recommended for the treatment of all forms of herpetic disorders.


Phenolic Compound Quercetin Catechin Rutin Zovirax 
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  1. 1.
    Flora of Georgia [in Russian], Metsniereba, Tbilisi (1985), Vol. X, p. 25.Google Scholar
  2. 2.
    Flora of the USSR [in Russian], USSR Acad. Sci., Moscow (1952), Vol. XVIII, p. 31.Google Scholar
  3. 3.
    V. S. Bostoganashvili, E. P. Kemertelidze, in: A Collection of Papers of the Institute of Pharmaceutical Chemistry [in Russian], Tbilisi, Gruzmedgiz (1956), Issue VIII, pp. 25–29.Google Scholar
  4. 4.
    D. M. Gedevanishvili and M. R. Tsereteli, in: A Collection of Papers of the Institute of Pharmaceutical Chemistry [in Russian], Tbilisi, Gruzmedgiz (1956), Issue VIII, pp. 69–82; 83–90.Google Scholar
  5. 5.
    R. Borkovski and S. Gzyszevska, Ball Inst. Rocs. Hccrn., 4, 340–357 (1958).Google Scholar
  6. 6.
    T. Swain and W. E. Hills, Sci. Food Agric., 10, 63–70 (1959).CrossRefGoogle Scholar
  7. 7.
    E. P. Kemertelidze and K. G. Shalashvili, Soobshch. Akad. Nauk. Gruzii, 170(3), 533–535 (2004).Google Scholar
  8. 8.
    G. F. Lakin, Biometrics [in Russian], Vysshaya Shkola, Moscow (1990).Google Scholar
  9. 9.
    M. Jondal and H. Klein, J. Exp. Med., 138, 1365–1368 (1973).PubMedCrossRefGoogle Scholar
  10. 10.
    G. Manchini, A. Carbonara, and G. Hermans, Int. J. Immunochem., 2, 235–254 (1965).Google Scholar
  11. 11.
    E. A. Kost and M. N. Stepko, A Handbook of Clinical Investigation Methods [in Russian], Meditsina, Moscow (1975).Google Scholar
  12. 12.
    V. D. Solov’ev and T. A. Bektmirov, Interferons in Theory and Practice of Medicine [in Russian], Meditsina, Moscow (1981).Google Scholar
  13. 13.
    A. G. Bukrinskaya, Virology [in Russian], Meditsina, Moscow (1992).Google Scholar
  14. 14.
    A. Simmons, P. Tscharke, and P. Speck, Curr. Topics Microbiol. Immunol., 179, 31–56 (1992).Google Scholar
  15. 15.
    M. A. Samgin, O. L. Ivanov, S. A. Kuzheleva, et al., Vestn. Dermatol., No. 3, 71–74 (1990).Google Scholar
  16. 16.
    M. R. Johnson, B. M. Korsantia, and A. G. Gachechiladze, Georgian Med. News, 9(102), 82–83 (2003).Google Scholar
  17. 17.
    G. T. Sukhikh, L. V. Van’ko, and V. I. Kulakov, Immunity and Genital Herpes [in Russian], NTSAGiP RAMN, Nizhni Novgorod, (1997).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • E. P. Kemertelidze
    • 1
  • K. G. Shalashvili
    • 1
  • B. M. Korsantiya
    • 2
  • N. O. Nizharadze
    • 2
  • N. Sh. Chipashvili
    • 2
  1. 1.Kutateladze Institute of Pharmaceutical ChemistryAcademy of Sciences of GeorgiaTbilisiRepublic of Georgia
  2. 2.Tbilisi State Medical UniversityTbilisiRepublic of Georgia

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