Pharmaceutical Chemistry Journal

, Volume 40, Issue 2, pp 61–62 | Cite as

Studying phenozan acid metabolism in rabbits

  • A. A. Prokopov
  • L. V. Shukil’
  • A. S. Berlyand
Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
Received:

Abstract

The metabolism of a new antioxidant agent — phenozan acid — was studied in rabbits. The main directions of this process are (i) oxidation of benzene ring with the formation of 2,6-di-tert-butyl-p-benzoquinone and (ii) dehydration of the propionic acid fragment with the formation of 4-hydroxy-3,5-di-tert-butylphenylacrylic acid methyl ester. The structures of metabolites were established by computer-aided gas chromatography/ mass spectrometry and confirmed by direct synthesis.

Keywords

Acid Methyl Ester Mass Selective Detector Methylsilicon Quadrupole Mass Analyzer Peroral Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. 1.
    V. V. Ershov, G. A. Nikiforov, and A. A. Volod’kin, Spatially Constrained Phenols [in Russian], Khimiya, Moscow (1972).Google Scholar
  2. 2.
    A. A. Prokopov, A. S. Berlyand, N. V. Veselovskaya, et al., Khim.-Farm. Zh., 34(5), 49–51 (2000).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • A. A. Prokopov
    • 1
  • L. V. Shukil’
    • 1
  • A. S. Berlyand
    • 1
  1. 1.Moscow State University of Medicine and DentistryMoscowRussia

Personalised recommendations