Pharmaceutical Chemistry Journal

, Volume 39, Issue 7, pp 350–353 | Cite as

Synthesis and Antiarrhythmic Activity of 2-Diethylamino-2′,6′-Dimethylphenylacetamide Derivatives

  • L. N. Sernov
  • S. Ya. Skachilova
  • D. S. Blinov
  • V. V. Druzhinina
  • Ya. V. Kostin
  • E. V. Shilova
Search for New Drugs

Abstract

Data on the syntheses and structures of a series of new derivatives of 2-diethylamino-2′,6′-dimethylphenylacetamide are described. The results of an experimental study of the new compounds on various arrhythmia models in animals are presented. Several substances effectively preventing the onset of ventricular ischemia, reperfusive and toxic fibrillation, and ischemic arrhythmia have been selected, which are superior to the reference drug lidocaine with respect to their antiarrhythmic properties.

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • L. N. Sernov
    • 1
  • S. Ya. Skachilova
    • 1
  • D. S. Blinov
    • 2
  • V. V. Druzhinina
    • 1
  • Ya. V. Kostin
    • 2
  • E. V. Shilova
    • 1
  1. 1.All-Russia Scientific Center for Safety Testing of Biologically Active SubstancesMinistry of Public Health of the Russian FederationStaraya Kupavna, Moscow oblastRussia
  2. 2.Mordvinian State UniversitySaransk, MordviniaRussia

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