Pharmaceutical Chemistry Journal

, Volume 39, Issue 7, pp 350–353 | Cite as

Synthesis and Antiarrhythmic Activity of 2-Diethylamino-2′,6′-Dimethylphenylacetamide Derivatives

  • L. N. Sernov
  • S. Ya. Skachilova
  • D. S. Blinov
  • V. V. Druzhinina
  • Ya. V. Kostin
  • E. V. Shilova
Search for New Drugs


Data on the syntheses and structures of a series of new derivatives of 2-diethylamino-2′,6′-dimethylphenylacetamide are described. The results of an experimental study of the new compounds on various arrhythmia models in animals are presented. Several substances effectively preventing the onset of ventricular ischemia, reperfusive and toxic fibrillation, and ischemic arrhythmia have been selected, which are superior to the reference drug lidocaine with respect to their antiarrhythmic properties.


Ischemia Experimental Study Organic Chemistry Lidocaine Reference Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    T. Fazekas, B. J. Scherlag, P. Mabo, et al., Acta Physiol. Hung., 82(3), 201–213 (1994).PubMedGoogle Scholar
  2. 2.
    N. J. Nasir, A. Taylor, T. K. Doyle, and A. Pacifico, Am. J. Cardiol., 74(12), 1183–1186 (1994).CrossRefPubMedGoogle Scholar
  3. 3.
    C. Pharand, J. Kluger, E. O'Rangers, et al., Clin. Pharm. and Therap., 54, 471–478 (1995).Google Scholar
  4. 4.
    V. A. Kryzhanovskii, Diagnostics and Treatment of Myocardial Infarction [in Russian], Fenix, Kiev (2001).Google Scholar
  5. 5.
    H. J. Trappe and P. Pfitzner, Z. Kardiol., 90(4), 36–44 (2001).PubMedGoogle Scholar
  6. 6.
    L. N. Sernov, I. V. Pashina, E. N. Pashin, et al., in: Proceedings of the 1st Meeting of the Russian Scientific Society of Pharmacists [in Russian], Volgograd (1995), p. 331.Google Scholar
  7. 7.
    V. V. Poroikov and D. A. Filimonov, Scholar
  8. 8.
    M. L. Belen'kii, Elements of the Quantitative Evaluation of the Pharmacological Effect [in Russian], Zinatne, Riga (1963).Google Scholar
  9. 9.
    L. N. Sernov and V. V. Gatsura, Elements of Experimental Pharmacology [in Russian], Nauka, Moscow (2000).Google Scholar
  10. 10.
    B. G. Storozhuk, Farmakol. Toksikol., No. 3, 47–49 (1985).Google Scholar
  11. 11.
    A. Manning, R. Grome, K. Istcol, et al., Adv. Myocardiol., 6, 515–522 (1986).Google Scholar
  12. 12.
    M. R. Malinow, F. F. Battle, and B. Malamud, Circ. Res., 1(6), 554–559 (1953).PubMedGoogle Scholar
  13. 13.
    L. N. Sernov, S. Ya. Skachilova, D. S. Blinov, et al., RF Patent No. 2223263.Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • L. N. Sernov
    • 1
  • S. Ya. Skachilova
    • 1
  • D. S. Blinov
    • 2
  • V. V. Druzhinina
    • 1
  • Ya. V. Kostin
    • 2
  • E. V. Shilova
    • 1
  1. 1.All-Russia Scientific Center for Safety Testing of Biologically Active SubstancesMinistry of Public Health of the Russian FederationStaraya Kupavna, Moscow oblastRussia
  2. 2.Mordvinian State UniversitySaransk, MordviniaRussia

Personalised recommendations