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Origins of Life and Evolution of Biospheres

, Volume 43, Issue 6, pp 491–500 | Cite as

A New Criterion for Demarcating Life from Non-Life

  • J. H. van Hateren
Astrobiology

Abstract

Criteria for demarcating life from non-life are important for deciding whether new candidate systems, either discovered extraterrestrially or constructed in the laboratory, are genuinely alive or not. They are also important for understanding the origin of life and its evolution. Current criteria are either too restrictive or too extensive. The new criterion proposed here poses that a system is living when it is capable of utilizing active causation, at evolutionary or behavioural timescales. Active causation is produced when the organism uses an estimate of its own Darwinian fitness to modulate the variance of stochasticity that drives hereditary or behavioural changes. The changes are subsequently fed back to the fitness estimate and used in the next cycle of a feedback loop. The ability to use a self-estimated fitness in this way is an evolved property of the organism, and the way in which fitness is estimated is therefore controlled and stabilized by Darwinian evolution. The hereditary and behavioural trajectories resulting from this mechanism combine predictability with unpredictability, and the mechanism produces a form of self-directed agency in living organisms that is absent from non-living systems.

Keywords

Active causation Agency Darwinian evolution Definition of life Spontaneity 

References

  1. Al Mamun AA, Lombardo MJ, Shee C, Lisewski AM, Gonzalez C, Lin D, Nehring RB, Saint-Ruf C, Gibson JL, Frisch RL, Lichtarge O, Hastings PJ, Rosenberg SM (2012) Identity and function of a large gene network underlying mutagenic repair of DNA breaks. Science 338:1344–1348PubMedCentralPubMedCrossRefGoogle Scholar
  2. Bedau MA (2007) What is life? In: Sarkar S, Plutynski A (eds) A companion to the philosophy of biology. Blackwell, New York, pp 455–471CrossRefGoogle Scholar
  3. Benner SA (2010) Defining life. Astrobiology 10:1021–1030PubMedCentralPubMedCrossRefGoogle Scholar
  4. Burgin M (2010) Theory of information: fundamentality, diversity and unification. World Scientific, SingaporeGoogle Scholar
  5. Cleland CE (2012) Life without definitions. Synthese 185:125–144CrossRefGoogle Scholar
  6. Cleland CE, Chyba CF (2002) Defining ‘life’. Orig Life Evol Biosph 32:387–393PubMedCrossRefGoogle Scholar
  7. Darwin C (1859) On the origin of species by means of natural selection. J. Murray, LondonGoogle Scholar
  8. Di Paolo EA (2005) Autopoiesis, adaptivity, teleology, agency. Phenomenol Cogn Sci 4:429–452CrossRefGoogle Scholar
  9. Eigen M (1971) Selforganization of matter and evolution of biological macromolecules. Naturwissenschaften 58:465–523PubMedCrossRefGoogle Scholar
  10. Galhardo RS, Hastings PJ, Rosenberg SM (2007) Mutation as a stress response and the regulation of evolvability. Crit Rev Biochem Mol Biol 42:399–435PubMedCentralPubMedCrossRefGoogle Scholar
  11. Kauffman SA (2000) Investigations. Oxford University Press, New YorkGoogle Scholar
  12. Kauffman SA (2003) Molecular autonomous agents. Phil Trans R Soc Lond A 361:1089–1099CrossRefGoogle Scholar
  13. Laskar J, Gastineau M (2009) Existence of collisional trajectories of Mercury, Mars and Venus with the Earth. Nature 459:817–819PubMedCrossRefGoogle Scholar
  14. Lineweaver CH, Egan CA (2008) Life, gravity and the second law of thermodynamics. Phys Life Rev 5:225–242CrossRefGoogle Scholar
  15. MacLean RC, Torres-Barceló C, Moxon R (2013) Evaluating evolutionary models of stress-induced mutagenesis in bacteria. Nat Rev Genet 14:221–227PubMedCrossRefGoogle Scholar
  16. Macnab RM, Koshland DE Jr (1972) The gradient-sensing mechanism in bacterial chemotaxis. Proc Natl Acad Sci U S A 69:2509–2512PubMedCentralPubMedCrossRefGoogle Scholar
  17. Maynard Smith J (2000) The concept of information in biology. Philos Sci 67:177–194CrossRefGoogle Scholar
  18. Michel D (2013) Life is a self-organizing machine driven by the informational cycle of Brillouin. Orig Life Evol Biosph 43:137–150PubMedCrossRefGoogle Scholar
  19. Nurse P (2008) Life, logic and information. Nature 454:424–426PubMedCrossRefGoogle Scholar
  20. Pross A (2004) Causation and the origin of life. Metabolism or replication first? Orig Life Evol Biosph 34:307–321PubMedCrossRefGoogle Scholar
  21. Ram Y, Hadany L (2012) The evolution of stress-induced hypermutation in asexual populations. Evolution 66:2315–2328PubMedCrossRefGoogle Scholar
  22. Ruiz-Mirazo K, Peretó J, Moreno A (2004) A universal definition of life: autonomy and open-ended evolution. Orig Life Evol Biosph 34:323–346PubMedCrossRefGoogle Scholar
  23. Shee C, Gibson JL, Darrow MC, Gonzalez C, Rosenberg SM (2011) Impact of a stress-inducible switch to mutagenic repair of DNA breaks on mutation in Escherichia coli. Proc Natl Acad Sci U S A 108:13659–13664PubMedCentralPubMedCrossRefGoogle Scholar
  24. Stano P, Luisi PL (2010) Achievements and open questions in the self-reproduction of vesicles and synthetic minimal cells. Chem Commun 46:3639–3653CrossRefGoogle Scholar
  25. Szathmáry E, Maynard Smith J (1995) The major evolutionary transitions. Nature 374:227–232PubMedCrossRefGoogle Scholar
  26. Thompson E (2007) Mind in life: biology, phenomenology, and the sciences of mind. Belknap, CambridgeGoogle Scholar
  27. Tsokolov SA (2009) Why is the definition of life so elusive? Epistemological considerations. Astrobiology 9:401–412PubMedCrossRefGoogle Scholar
  28. van Hateren JH (2013) Active causation and the origin of meaning. arXiv:1310.2063 [q-bio.PE] http://arxiv.org/abs/1310.2063
  29. Varela FG, Maturana HR, Uribe R (1974) Autopoiesis: the organization of living systems, its characterization and a model. BioSystems 5:187–196CrossRefGoogle Scholar
  30. Walker SI, Davies PCW (2012) The algorithmic origins of life. J R Soc Interface 10:20120869PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Johann Bernouilli Institute for Mathematics and Computer ScienceUniversity of GroningenGroningenThe Netherlands

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