Origins of Life and Evolution of Biospheres

, Volume 42, Issue 4, pp 333–346 | Cite as

Chiral Polymerization in Open Systems From Chiral-Selective Reaction Rates

  • Marcelo Gleiser
  • Bradley J. Nelson
  • Sara Imari Walker
Models for Homochirality

Abstract

We investigate the possibility that prebiotic homochirality can be achieved exclusively through chiral-selective reaction rate parameters without any other explicit mechanism for chiral bias. Specifically, we examine an open network of polymerization reactions, where the reaction rates can have chiral-selective values. The reactions are neither autocatalytic nor do they contain explicit enantiomeric cross-inhibition terms. We are thus investigating how rare a set of chiral-selective reaction rates needs to be in order to generate a reasonable amount of chiral bias. We quantify our results adopting a statistical approach: varying both the mean value and the rms dispersion of the relevant reaction rates, we show that moderate to high levels of chiral excess can be achieved with fairly small chiral bias, below 10%. Considering the various unknowns related to prebiotic chemical networks in early Earth and the dependence of reaction rates to environmental properties such as temperature and pressure variations, we argue that homochirality could have been achieved from moderate amounts of chiral selectivity in the reaction rates.

Keywords

Prebiotic chemistry Chirality Exoplanets 

References

  1. Bailey J (2001) Astronomical sources of circularly polarized light and the origin of homochirality. Orig Life Evol Biosph 31:167–183PubMedCrossRefGoogle Scholar
  2. Bakasov A, Ha TK, Quack M (1998) Ab initio calculation of molecular energies including parity violating interactions. J Chem Phys 109:7263–7285CrossRefGoogle Scholar
  3. Benner SA, Ricardo A, Carrigan MA (2004) Is there a common chemical model for life in the universe? Curr Opin Chem Biol 8:672–689PubMedCrossRefGoogle Scholar
  4. Bonner WA (1995) The Quest for Chirality. In: Cline D (ed) Physical origin of homochirality in life. AIP conference proceedings, vol 379. AIP Press, New YorkGoogle Scholar
  5. Chyba C, Sagan C (1992) Endogenous production, exogenous delivery and impact-shock synthesis of organic-molecules—an inventory for the origins of life. Nature 355:125–132PubMedCrossRefGoogle Scholar
  6. Corliss JB, Baross JA, Hoffman SE (1981) An hypothesis concerning the relationship between submarine hot springs and the origin of life on earth. Oceanol Acta 4:59–69Google Scholar
  7. Cronin JR, Pizzarello S (1997) Enantiomeric excesses in meteoritic amino acids. Science 275:951–955PubMedCrossRefGoogle Scholar
  8. Davies PCW (1996) The Transfer of Viable Microorganisms between Planets. In: Bock GR, Goode JA (eds) Evolution of hydrothermal ecosystems on earth (and Mars?). John Wiley & Sons, England, pp 304–317Google Scholar
  9. Davies PCW, Benner SA, Cleland CE, Lineweaver CH, McKay CP, Wolfe-Simon F (2009) Signatures of a Shadow Biosphere. Astrobiology 9:241–249PubMedCrossRefGoogle Scholar
  10. Crick FHC, Orgel LE (1973) Directed Panspermia. Icarus 19:341–348CrossRefGoogle Scholar
  11. Dunitz JD (1996) Symmetry arguments in chemistry. PNAS 93:14260–14266PubMedCrossRefGoogle Scholar
  12. Fitz D, Reiner H, Plankensteiner K, Rode BM (2007) Possible Origins of Biohomochirality. Curr Chem Biol 1:41–52CrossRefGoogle Scholar
  13. Frank F (1953) On spontaneous asymmetric synthesis. Biochim Biophys Acta 11:459–463PubMedCrossRefGoogle Scholar
  14. Fraser DG, Fitz D, Jakschitz T, Rode BM (2011) Selective adsorption and chiral amplification of amino acids in vermiculite clay-implications for the origin of biochirality. Phys Chem Chem Phys 13:831–838PubMedCrossRefGoogle Scholar
  15. Gilbert W (1986) Origin of life—the RNA world. Nature 319:618CrossRefGoogle Scholar
  16. Glavin DP, Dworkin JP (2009) Enrichment of the amino acid L-isovaline by aqueous alteration on CI and CM meteorite parent bodies. PNAS 106:5487–5492PubMedCrossRefGoogle Scholar
  17. Gleiser M, Walker SI (2008) An extended model for the evolution of prebiotic homochirality: A bottom-up approach to the origin of life. Orig Life Evol Biosph 38:293–315PubMedCrossRefGoogle Scholar
  18. Gleiser M, Thorarinson J, Walker SI (2008) Punctuated Chirality. Orig Life Evol Biosph 38:499–508PubMedCrossRefGoogle Scholar
  19. Gomes R, Levinson HF, Tsiganis K, Morbidelli A (2005) Origin of the cataclysmic Late Heavy Bombardment period of the terrestrial planets. Nature 435:466–469PubMedCrossRefGoogle Scholar
  20. Hazen R, Sholl D (2003) Chiral selection on inorganic crystalline surfaces. Nature Materials 2:367–374PubMedCrossRefGoogle Scholar
  21. Hochberg D (2009) Effective potential and chiral symmetry breaking. Phys Rev Lett 102:24801. Ibid. (2010) Phys Rev E 81:016106Google Scholar
  22. Joshi PC, Pitsch S, Ferris JP (2007) Selectivity of montmorillonite catalyzed prebiotic reactions of D, L-nucleotides. Orig Life Evol Biosph 37:3–26PubMedCrossRefGoogle Scholar
  23. Kondepudi DK, Nelson GW (1985) Weak neutral currents and the origin of biomolecular chirality. Nature 314:438–441CrossRefGoogle Scholar
  24. Landau LD, Lifshitz EM (1980) Statistical Physics. Butterworth-Heinemann, OxfordGoogle Scholar
  25. Martins Z, Botta O, Fogel ML, Sephton MA, Glavin DP, Watson JS, Dworkin JP, Schwartz AW, Ehrenfreund P (2008) Extraterrestrial nucleobases in the Murchison meteorite. Earth Planet Sci Lett 270:130–136CrossRefGoogle Scholar
  26. McKay C (2010) An origin of life on Mars. Cold Spring Harb Perspect Biol 2:a003509PubMedCrossRefGoogle Scholar
  27. Mojzsis SJ, Arrhenius G, McKeegan KD, Harrison TM, Nutman AP, Friend CR (1996) Evidence for life on Earth before 3,800 million years ago. Nature 384:55–59PubMedCrossRefGoogle Scholar
  28. Plasson R, Bersini H, Commeyras A (2004) Recycling frank: spontaneous emergence of homochirality in noncatalytic systems. Proc Natl Acad Sci 101:16733PubMedCrossRefGoogle Scholar
  29. Orgel LE (2010) The Origin of Life: a review of facts and speculation. In: Bedau MA and Cleland CE (eds) The Nature of Life. Cambridge University Press, Cambridge, pp 121–128Google Scholar
  30. Saito Y and Hyuga H (2005) Chirality selection in crystallization. J Phys Soc Japan 74:535–537CrossRefGoogle Scholar
  31. Salam A (1991) The role of chirality in the origin of life. J Mol Evol 33:105–113CrossRefGoogle Scholar
  32. Sandars PGH (2003) A toy model for the generation of homochirality during polymerization. Orig Life Evol Biosph 33:575–587PubMedCrossRefGoogle Scholar
  33. Sullivan WT III and Baross J (eds) (2007) Planets and life: the emerging science of astrobiology. Cambridge University Press, CambridgeGoogle Scholar
  34. Wattis JAD, Coveney PV (2005) Symmetry-breaking in chiral polymerisation. Orig Life Evol Biosph 35:243PubMedCrossRefGoogle Scholar
  35. Wattis, JAD, Coveney, PV (2007) Sequence selection during copolymerization. J Phys Chem B 111:9546–9562PubMedCrossRefGoogle Scholar
  36. Yamagata Y (1966) A hypothesis for asymmetric appearance of biomolecules on earth. J Theor Biol 11:495–498PubMedCrossRefGoogle Scholar
  37. van Zuilen MA, Lepland A, Arrhenius G (2002) Reassessing the evidence for the earliest traces of life. Nature 420:202CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Marcelo Gleiser
    • 1
  • Bradley J. Nelson
    • 1
  • Sara Imari Walker
    • 2
    • 3
  1. 1.Department of Physics and AstronomyDartmouth CollegeHanoverUSA
  2. 2.NASA Astrobiology InstituteMountain ViewUSA
  3. 3.BEYOND: Center for Fundamental Concepts in ScienceArizona State UniversityTempeUSA

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