Life Began When Evolution Began: A Lipidic Vesicle-Based Scenario

Prebiotic Chemistry


The research on the origin of life, as such, seems to have reached an impasse as a clear and universal scientific definition of life is probably impossible. On the contrary, the research on the origin of evolution may provide a clue. But it is necessary to identify the minimum requirements that allowed evolution to emerge on early Earth. The classical approach, the ‘RNA world hypothesis’ is one way, but an alternative based on nonlinear dynamics dealing with far-from-equilibrium self-organization and dissipative structures can also be proposed. The conditions on early Earth, near deep-sea hydrothermal sites, were favorable to the emergence of dissipative structures such as vesicles with bilayer membranes composed of a mixture of amphiphilic and hydrophobic molecules. Experimentally these vesicles are able to self-reproduce but not to evolve. A plausible scenario for the emergence of a positive feedback process giving them the capability of evolving on early Earth is suggested. The possibilities offered by such a process are described in regard to specific characteristics of extant biological organisms and leads for future research in the field are suggested.


Origin of life Origin of evolution Early earth Nonlinear dynamics Vesicles Fatty acids Membrane catalysis Species Positive feed-back process 


  1. Bada JL, Lazcano A (2002) Origin of life. Some like it hot, but not the first biomolecules. Science 296:1982–1983CrossRefPubMedGoogle Scholar
  2. Brasier MD et al (2002) Questioning the evidence for Earth’s oldest fossils. Nature 416:76–81CrossRefPubMedGoogle Scholar
  3. Coveney PV (2003) Self-organization and complexity: a new age for theory, computation and experiment. Phil Trans R Soc Lond 361:1057–1079CrossRefGoogle Scholar
  4. Depew DJ, Weber BH (1995) Darwinism Evolving The MIT Press, LondonGoogle Scholar
  5. Garcia-Ruiz JM, Hyde ST, Carnerup AM, Christy AG, Van Kranendonk MJ, Welham NJ (2003) Self-assembled silica-carbonate structures and detection of ancient microfossils. Science 302:1194–1197CrossRefPubMedGoogle Scholar
  6. Hagmann M (2002) Between a rock and a hard place. Science 295:2006–2007CrossRefPubMedGoogle Scholar
  7. Kelley DS et al (2005) A serpentine-hosted ecosystem: the Lost City hydrothermal field. Science 307:1428–1434CrossRefPubMedGoogle Scholar
  8. Holm NG, Charlou JL (2001) Initial indications of abiotic formation of hydrocarbons in the rainbow ultramafic hydrothermal system, mild-atlantic ridge. Earth Planet Sci Lett 191:1–8CrossRefGoogle Scholar
  9. Luisi PL, Rasi PS, Mavelli F (2004) A possible route to prebiotic vesicule reproduction. Artif Life 10:297–308CrossRefPubMedGoogle Scholar
  10. Luisi PL (2006) The emergence of life - from chemical origins to synthetic biology. Cambridge University Press, New YorkGoogle Scholar
  11. Namani T, Deamer DW (2008) Stability of model membranes in extreme environments. Orig Life Evol Biosph 38:329–341CrossRefPubMedGoogle Scholar
  12. Nisbet EG, Sleep NH (2001) The habitat and nature of early life. Nature 409:1083–1091CrossRefPubMedGoogle Scholar
  13. Orgel LE (2000) Self-organizing biochemical cycles. Proc Natl Acad Sci USA 97:12503–12507CrossRefPubMedGoogle Scholar
  14. Powner MW, Gerland B, Sutherland JD (2009) Synthesis of activated pyrimidine ribonucleides in prebiotically plausible conditions. Nature 459:239–242CrossRefPubMedGoogle Scholar
  15. Rajamani S, Vlassov A, Benner S, Coombs A, Olasagasti F, Deamer D (2008) Lipid-assisted Synthesis of RNA-like polymers from mononucleotides. Orig Life Evol Biosph 38:57–74CrossRefPubMedGoogle Scholar
  16. Rasi S, Mavelli F, Luisi PL (2004) Matrix effect in oleate micelles-vesicles transformation. Orig Life Evol Biosph 34:215–224CrossRefPubMedGoogle Scholar
  17. Rasmussen B (2000) Filamentous microfossils in a 3, 235-million-year-old volcanogenic massive sulphide deposit. Nature 405:676–679CrossRefPubMedGoogle Scholar
  18. Rusdhi AI, Simoneit BRT (2006) Abiotic condensation synthesis of glyceride lipids and wax esters under simulated hydrothermal conditions. Orig Life Evol Biosph 36:93–108CrossRefGoogle Scholar
  19. Schopf JW, Kudryavtsev AB, Agresti DG, Wdowiak TJ, Czaja AD (2002) Laser-raman imagery of earth’s earliest fossils. Nature 416:73–76Google Scholar
  20. Segré D, Ben-Eli D, Deamer DW, Lancet D (2001) The lipid world. Orig Life Evol Biosph 31:119–145CrossRefPubMedGoogle Scholar
  21. Skar J (2003) Introduction: self-organization as an actual theme. Phil Trans R Soc Lond 361:1049–1056CrossRefGoogle Scholar
  22. Tabony J, Job D (1990) Spatial structures in microtubular solutions requiring a sustained energy source. Nature 346:448–451CrossRefPubMedGoogle Scholar
  23. Walde P (2006) Surfactant assemblies and their various possible roles for the origin(s) of life. Orig Life Evol Biosph 36:109–150CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.MeudonFrance

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