Condensation of amino acids to form peptides in aqueous solution induced by the oxidation of sulfur(iv): An oxidative model for prebiotic peptide formation
- 228 Downloads
Condensation of amino acids to peptides is an important step during the origin of life. However, up to now, successful explanations for plausible prebiotic peptide formation pathways have been limited. Here we report that the oxidation of sulfur (IV) can induce the condensation reaction of carboxylic acids and amines to form amides, and the condensation reaction of amino acids to form peptides. This might be a general reaction contributing to prebiotic peptide formation.
KeywordsCondensation Sulfur dioxide Amino acid Oxidation Prebiotic peptide formation
Unable to display preview. Download preview PDF.
- Brandt C, Fabian I, Vaneldik R (1994) Kinetics and mechanism of the iron(III)-catalyzed autoxidation of sulfur(IV) Oxides in aqueous solution. Evidence for the redox cycling of iron in the presence of oxygen and modeling of the overall reaction mechanism. Inorg Chem 33:687–701Google Scholar
- Brandt C, Vaneldik R (1995) Transition metal-catalyzed oxidation of sulfur(IV) oxides. Atmospheric-relevant processes and mechanisms. Chem Rev 95:119–190Google Scholar
- Clayton DW, Farrington JA, Kenner GW, Turner JM (1957) Peptides. Part VI. Further studies of the synthesis of peptides through anhydrides of sulphuric acid. J Chem Soc 1398–1407Google Scholar
- Kenner GW, Stedman RJ (1952) Peptides. Part I. The Synthesis of Peptides through Anhydrides of Sulphuric Acid. J Chem Soc 2069–2076Google Scholar
- Schwendinger MG, Rode BM (1989) Possible role of copper and sodium chloride in prebiotic evolution of peptides. Anal Sci 5:411–414Google Scholar
- Symonds RB, Rose WI, Bluth GJS, Gerlach TM (1994) Volcanic-Gas studies: Methods, Results, and Applications. Rev Mineral 30:1–66Google Scholar