Homochiral Growth Through Enantiomeric Cross-Inhibition


The stability and conservation properties of a recently proposed polymerization model are studied. The achiral (racemic) solution is linearly unstable once the relevant control parameter (here the fidelity of the catalyst) exceeds a critical value. The growth rate is calculated for different fidelity parameters and cross-inhibition rates. A chirality parameter is defined and shown to be conserved by the nonlinear terms of the model. Finally, a truncated version of the model is used to derive a set of two ordinary differential equations and it is argued that these equations are more realistic than those used in earlier models of that form.

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Correspondence to A. Brandenburg.

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Brandenburg, A., Andersen, A.C., Höfner, S. et al. Homochiral Growth Through Enantiomeric Cross-Inhibition. Orig Life Evol Biosph 35, 225–241 (2005) doi:10.1007/s11084-005-0656-9

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  • DNA polymerization
  • enantiomeric cross-inhibition
  • origin of homochirality