Neuropsychology Review

, Volume 27, Issue 1, pp 18–30 | Cite as

Disrupted Face Processing in Frontotemporal Dementia: A Review of the Clinical and Neuroanatomical Evidence

  • Rosalind Hutchings
  • Romina Palermo
  • Olivier Piguet
  • Fiona Kumfor
Review

Abstract

Faces play an integral role in day-to-day functioning, particularly for social interactions where dynamic and rapid processing of information is vital. Analysis of faces allows an individual to ascertain a wide range of information including deciphering mood and identity, with these assessments directing an individual’s subsequent response and behaviours. The prominent social and emotional deficits observed in frontotemporal dementia (FTD), a younger-onset dementia syndrome, may in part reflect a breakdown of the face processing network. Different subtypes of FTD present with divergent patterns of atrophy, although damage is predominantly confined to the frontal and temporal lobes. Specific predictions regarding the role of frontal and temporal regions in face processing have been proposed in the model outlined by Haxby et al. Trends in Cognitive Sciences, 4(6), 223–233 (2000). This model presents a parsimonious method by which to understand face processing in FTD while concurrently allowing assessment of the predictive value and applicability of such a model. By applying the Haxby model to the existing FTD literature, this review presents both direct and indirect evidence of a breakdown in key elements of the face processing network. The type and degree of breakdown appears to differ as a function of FTD subtype and associated brain atrophy. The evidence presented in this review and its relationship with predictions of the Haxby model provides impetus and direction for future research investigating face processing in FTD.

Keywords

Behavioural-variant frontotemporal dementia Semantic dementia Progressive nonfluent aphasia Emotion Identity Neuroimaging 

References

  1. Adenzato, M., Cavallo, M., & Enrici, I. (2010). Theory of mind ability in the behavioural variant of frontotemporal dementia: an analysis of the neural, cognitive, and social levels. Neuropsychologia, 48(1), 2–12.PubMedCrossRefGoogle Scholar
  2. Adolphs, R. (2002). Neural systems for recognizing emotion. Current Opinion in Neurobiology, 12(2), 169–177.PubMedCrossRefGoogle Scholar
  3. Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. R. (1995). Fear and the human amygdala. The Journal of Neuroscience, 15(9), 5879–5891.PubMedGoogle Scholar
  4. Adolphs, R., Gosselin, F., Buchanan, T. W., Tranel, D., Schyns, P., & Damasio, A. R. (2005). A mechanism for impaired fear recognition after amygdala damage. Nature, 433, 68–72.PubMedCrossRefGoogle Scholar
  5. Avidan, G., & Behrmann, M. (2009). Functional MRI reveals compromised neural integrity of the face processing network in congenital prosopagnosia. Current Biology, 19(13), 1146–1150.PubMedPubMedCentralCrossRefGoogle Scholar
  6. Avidan, G., Tanzer, M., Hadj-Bouziane, F., Liu, N., Ungerleider, L. G., & Behrmann, M. (2014). Selective dissociation between core and extended regions of the face processing network in congenital prosopagnosia. Cerebral Cortex, 24(6), 1565–1578.PubMedCrossRefGoogle Scholar
  7. Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001). The “reading the mind in the eyes” test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry, 42(2), 241–251.PubMedCrossRefGoogle Scholar
  8. Behrmann, M., Avidan, G., Gao, F., & Black, S. (2007). Structural imaging reveals anatomical alterations in inferotemporal cortex in congenital prosopagnosia. Cerebral Cortex, 17(10), 2354–2363.PubMedCrossRefGoogle Scholar
  9. Benton, A. L. (1994). Contributions to neuropsychological assessment: A clinical manual. New York: Oxford University Press.Google Scholar
  10. Bruce, V., & Young, A. (1986). Understanding face recognition. British Journal of Psychology, 77, 305–327.PubMedCrossRefGoogle Scholar
  11. Busigny, T., Robaye, L., Dricot, L., & Rossion, B. (2009). Right anterior temporal lobe atrophy and person-based semantic defect: a detailed case study. Neurocase, 15(6), 485–508.PubMedCrossRefGoogle Scholar
  12. Busigny, T., Van Belle, G., Jemel, B., Hosein, A., Joubert, S., & Rossion, B. (2014). Face-specific impairment in holistic perception following focal lesion of the right anterior temporal lobe. Neuropsychologia, 56, 312–333.PubMedCrossRefGoogle Scholar
  13. Calder, A. J., & Young, A. W. (2005). Understanding the recognition of facial identity and facial expression. Nature Reviews Neuroscience, 6(8), 641–651.PubMedCrossRefGoogle Scholar
  14. Chan, D., Anderson, V., Pijnenburg, Y., Whitwell, J., Barnes, J., Scahill, R., et al. (2009). The clinical profile of right temporal lobe atrophy. Brain, 132, 1287–1298.PubMedCrossRefGoogle Scholar
  15. Couto, B., Manes, F., Montañés, P., Matallana, D., & Reyes, P. (2013). Structural neuroimaging of social cognition in progressive non-fluent aphasia and behavioral variant of frontotemporal dementia. Frontiers in Human Neuroscience, 7(467), 1–11.Google Scholar
  16. Coyle-Gilchrist, I. T., Dick, K. M., Patterson, K., Rodríquez, P. V., Wehmann, E., Wilcox, A., et al. (2016). Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes. Neurology, 86(18), 1736–1743.PubMedPubMedCentralCrossRefGoogle Scholar
  17. De Renzi, E., Perani, D., Carlesimo, G. A., Silveri, M., & Fazio, F. (1994). Prosopagnosia can be associated with damage confined to the right hemisphere—an MRI and PET study and a review of the literature. Neuropsychologia, 32(8), 893–902.PubMedCrossRefGoogle Scholar
  18. De Winter, F.-L., Van den Stock, J., de Gelder, B., Peeters, R., Jastorff, J., Sunaert, S., et al. (2016a). Amygdala atrophy affects emotion-related activity in face-responsive regions in frontotemporal degeneration. Cortex, 81, 179–191.CrossRefGoogle Scholar
  19. De Winter, F.-L., Timmers, D., de Gelder, B., Van Orshoven, M., Vieren, M., Bouckaert, M., et al. (2016b). Face shape and face identity processing in behavioral variant fronto-temporal dementia: a specific deficit for familiarity and name recognition of famous faces. NeuroImage: Clinical, 11, 368–377.CrossRefGoogle Scholar
  20. Duchaine, B., & Nakayama, K. (2006). The Cambridge face memory test: results for neurologically intact individuals and an investigation of its validity using inverted face stimuli and prosopagnosic participants. Neuropsychologia, 44(4), 576–585.PubMedCrossRefGoogle Scholar
  21. Duchaine, B., & Weidenfeld, A. (2003). An evaluation of two commonly used tests of unfamiliar face recognition. Neuropsychologia, 41(6), 713–720.PubMedCrossRefGoogle Scholar
  22. Duchaine, B., & Yovel, G. (2015). A revised neural framework for face processing. Annual Review of Vision Science, 1, 393–416.CrossRefGoogle Scholar
  23. Edwards-Lee, T., Miller, B. L., Benson, D. F., Cummings, J. L., Russell, G. L., Boone, K., et al. (1997). The temporal variant of frontotemporal dementia. Brain, 120(6), 1027–1040.PubMedCrossRefGoogle Scholar
  24. Eimer, M. (2000). Event-related brain potentials distinguish processing stages involved in face perception and recognition. Clinical Neurophysiology, 111(4), 694–705.PubMedCrossRefGoogle Scholar
  25. Evans, J. J., Heggs, A., Antoun, N., & Hodges, J. R. (1995). Progressive prosopagnosia associated with selective right temporal lobe atrophy. Brain, 118(1), 1–13.PubMedCrossRefGoogle Scholar
  26. Farah, M. J., Wilson, K. D., Drain, M., & Tanaka, J. N. (1998). What is" special" about face perception? Psychological Review, 105(3), 482.PubMedCrossRefGoogle Scholar
  27. Galton, C. J., Patterson, K., Graham, K., Lambon-Ralph, M., Williams, G., Antoun, N., et al. (2001). Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia. Neurology, 57(2), 216–225.PubMedCrossRefGoogle Scholar
  28. Gefen, T., Wieneke, C., Martersteck, A., Whitney, K., Weintraub, S., Mesulam, M.-M., et al. (2013). Naming vs knowing faces in primary progressive aphasia a tale of 2 hemispheres. Neurology, 81(7), 658–664.PubMedPubMedCentralCrossRefGoogle Scholar
  29. Goren, C. C., Sarty, M., & Wu, P. Y. (1975). Visual following and pattern discrimination of face-like stimuli by newborn infants. Pediatrics, 56(4), 544–549.PubMedGoogle Scholar
  30. Gorno-Tempini, M. L., Price, C. J., Josephs, O., Vandenberghe, R., Cappa, S. F., Kapur, N., et al. (1998). The neural systems sustaining face and proper-name processing. Brain, 121(11), 2103–2118.PubMedCrossRefGoogle Scholar
  31. Gorno-Tempini, M. L., Hillis, A., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S., et al. (2011). Classification of primary progressive aphasia and its variants. Neurology, 76(11), 1006–1014.PubMedPubMedCentralCrossRefGoogle Scholar
  32. Gregory, C., Lough, S., Stone, V., Erzinclioglu, S., Martin, L., Baron-Cohen, S., et al. (2002). Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer’s disease: theoretical and practical implications. Brain, 125(4), 752–764.PubMedCrossRefGoogle Scholar
  33. Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2000). The distributed human neural system for face perception. Trends in Cognitive Sciences, 4(6), 223–233.PubMedCrossRefGoogle Scholar
  34. Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2002). Human neural systems for face recognition and social communication. Biological Psychiatry, 51(1), 59–67.PubMedCrossRefGoogle Scholar
  35. Hodges, J. R., & Patterson, K. (2007). Semantic dementia: A unique clinicopathological syndrome. The Lancet Neurology, 6(11), 1004–1014.PubMedCrossRefGoogle Scholar
  36. Hodges, J. R., Mitchell, J., Dawson, K., Spillantini, M. G., Xuereb, J. H., McMonagle, P., et al. (2010). Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases. Brain, 133(1), 300–306.PubMedCrossRefGoogle Scholar
  37. Hoffman, E. A., & Haxby, J. V. (2000). Distinct representations of eye gaze and identity in the distributed human neural system for face perception. Nature Neuroscience, 3(1), 80–84.PubMedCrossRefGoogle Scholar
  38. Hsieh, S., Hornberger, M., Piguet, O., & Hodges, J. R. (2011). Neural basis of music knowledge: evidence from the dementias. Brain, 134(9), 2523–2534.PubMedCrossRefGoogle Scholar
  39. Hutchings, R., Hodges, J. R., Piguet, O., & Kumfor, F. (2015). Why should I care? Dimensions of socio-emotional cognition in younger-onset dementia. Journal of Alzheimer's Disease, 48(1), 135–147.PubMedCrossRefGoogle Scholar
  40. Ibañez, A., & Manes, F. (2012). Contextual social cognition and the behavioral variant of frontotemporal dementia. Neurology, 78(17), 1354–1362.PubMedPubMedCentralCrossRefGoogle Scholar
  41. Irish, M., Kumfor, F., Hodges, J. R., & Piguet, O. (2013). A tale of two hemispheres: contrasting socioemotional dysfunction in right-versus left-lateralised semantic dementia; um conto sobre dois hemisférios: contrastando a disfunção socioemocional na demência semântica com atrofia lateralizada à direita versus esquerda. Dementia e Neuropsychologia, 7(1), 88–95.CrossRefGoogle Scholar
  42. Jesso, S., Morlog, D., Ross, S., Pell, M. D., Pasternak, S. H., Mitchell, D. G., et al. (2011). The effects of oxytocin on social cognition and behaviour in frontotemporal dementia. Brain, 134(9), 2493–2501.PubMedCrossRefGoogle Scholar
  43. Johnson, M. H., Dziurawiec, S., Ellis, H., & Morton, J. (1991). Newborns’ preferential tracking of face-like stimuli and its subsequent decline. Cognition, 40(1), 1–19.PubMedCrossRefGoogle Scholar
  44. Kamminga, J., Kumfor, F., Burrell, J. R., Piguet, O., Hodges, J. R., & Irish, M. (2014). Differentiating between right-lateralised semantic dementia and behavioural-variant frontotemporal dementia: an examination of clinical characteristics and emotion processing. Journal of Neurology, Neurosurgery & Psychiatry, 86, 1082–1088.CrossRefGoogle Scholar
  45. Kanwisher, N., & Yovel, G. (2006). The fusiform face area: a cortical region specialized for the perception of faces. Philosophical Transactions of the Royal Society, B: Biological Sciences, 361(1476), 2109–2128.PubMedCentralCrossRefGoogle Scholar
  46. Keane, J., Calder, A. J., Hodges, J. R., & Young, A. W. (2002). Face and emotion processing in frontal variant frontotemporal dementia. Neuropsychologia, 40(6), 655–665.PubMedCrossRefGoogle Scholar
  47. Kertesz, A., Davidson, W., McCabe, P., Takagi, K., & Munoz, D. (2003). Primary progressive aphasia: diagnosis, varieties, evolution. Journal of the International Neuropsychological Society, 9(05), 710–719.PubMedCrossRefGoogle Scholar
  48. Kumfor, F., & Piguet, O. (2012). Disturbance of emotion processing in frontotemporal dementia: a synthesis of cognitive and neuroimaging findings. Neuropsychology Review, 22(3), 280–297.PubMedCrossRefGoogle Scholar
  49. Kumfor, F., & Piguet, O. (2013). Emotion recognition in the dementias: brain correlates and patient implications. Neurodegenerative Disease Management, 3(3), 277–288.CrossRefGoogle Scholar
  50. Kumfor, F., Miller, L., Lah, S., Hsieh, S., Savage, S., Hodges, J. R., et al. (2011). Are you really angry? The effect of intensity on facial emotion recognition in frontotemporal dementia. Social Neuroscience, 6(5–6), 502–514.PubMedCrossRefGoogle Scholar
  51. Kumfor, F., Irish, M., Hodges, J. R., & Piguet, O. (2013). Discrete neural correlates for the recognition of negative emotions: insights from frontotemporal dementia. PloS One, 8(6), e67457.PubMedPubMedCentralCrossRefGoogle Scholar
  52. Kumfor, F., Hodges, J. R., & Piguet, O. (2014). Ecological assessment of emotional enhancement of memory in progressive nonfluent aphasia and Alzheimer’s disease. Journal of Alzheimer's Disease, 42(1), 201–210.PubMedGoogle Scholar
  53. Kumfor, F., Hutchings, R., Irish, M., Hodges, J. R., Rhodes, G., Palermo, R., et al. (2015). Do I know you? Examining face and object memory in frontotemporal dementia. Neuropsychologia, 71, 101–111.PubMedCrossRefGoogle Scholar
  54. Kumfor, F., Landin-Romero, R., Devenney, E., Hutchings, R., Grasso, R., Hodges, J. R., et al. (2016). On the right side? A longitudinal study of left-versus right-lateralized semantic dementia. Brain, 139(3), 1–13.CrossRefGoogle Scholar
  55. Lam, B. Y., Halliday, G. M., Irish, M., Hodges, J. R., & Piguet, O. (2014). Longitudinal white matter changes in frontotemporal dementia subtypes. Human Brain Mapping, 35(7), 3547–3557.PubMedCrossRefGoogle Scholar
  56. Lavenu, I., & Pasquier, F. (2005). Perception of emotion on faces in frontotemporal dementia and Alzheimer’s disease: a longitudinal study. Dementia and Geriatric Cognitive Disorders, 19(1), 37–41.PubMedCrossRefGoogle Scholar
  57. Lavenu, I., Pasquier, F., Lebert, F., Petit, H., & Van der Linden, M. (1999). Perception of emotion in frontotemporal dementia and Alzheimer disease. Alzheimer Disease & Associated Disorders, 13(2), 96–101.CrossRefGoogle Scholar
  58. Leyton, C. E., Britton, A. K., Hodges, J. R., Halliday, G. M., & Kril, J. J. (2016). Distinctive pathological mechanisms involved in primary progressive aphasias. Neurobiology of Aging, 38, 82–92.PubMedCrossRefGoogle Scholar
  59. Lindquist, K. A., Gendron, M., Barrett, L. F., & Dickerson, B. C. (2014). Emotion perception, but not affect perception, is impaired with semantic memory loss. Emotion, 14(2), 375.PubMedPubMedCentralCrossRefGoogle Scholar
  60. Lough, S., Kipps, C. M., Treise, C., Watson, P., Blair, J. R., & Hodges, J. R. (2006). Social reasoning, emotion and empathy in frontotemporal dementia. Neuropsychologia, 44(6), 950–958.PubMedCrossRefGoogle Scholar
  61. Marsh, A. A., & Blair, R. J. R. (2008). Deficits in facial affect recognition among antisocial populations: a meta-analysis. Neuroscience & Biobehavioral Reviews, 32(3), 454–465.CrossRefGoogle Scholar
  62. Mendez, M. F., Ringman, J. M., & Shapira, J. S. (2015). Impairments in the face-processing network in developmental prosopagnosia and semantic dementia. Cognitive and Behavioral Neurology, 28(4), 188–197.PubMedPubMedCentralCrossRefGoogle Scholar
  63. Miller, L. A., Hsieh, S., Lah, S., Savage, S., Hodges, J. R., & Piguet, O. (2012). One size does not fit all: face emotion processing impairments in semantic dementia, behavioural-variant frontotemporal dementia and Alzheimer’s disease are mediated by distinct cognitive deficits. Behavioural Neurology, 25(1), 53–60.PubMedCrossRefGoogle Scholar
  64. Mion, M., Patterson, K., Acosta-Cabronero, J., Pengas, G., Izquierdo-Garcia, D., Hong, Y. T., et al. (2010). What the left and right anterior fusiform gyri tell us about semantic memory. Brain, 133(11), 3256–3268.PubMedCrossRefGoogle Scholar
  65. Morton, J., & Johnson, M. H. (1991). CONSPEC and CONLERN: a two-process theory of infant face recognition. Psychological Review, 98(2), 164.PubMedCrossRefGoogle Scholar
  66. O’Toole, A. J., Roark, D. A., & Abdi, H. (2002). Recognizing moving faces: a psychological and neural synthesis. Trends in Cognitive Sciences, 6(6), 261–266.PubMedCrossRefGoogle Scholar
  67. Oliver, L. D., Virani, K., Finger, E. C., & Mitchell, D. G. V. (2014). Is the emotion recognition deficit associated with frontotemporal dementia caused by selective inattention to diagnostic facial features? Neuropsychologia, 60, 84–92.PubMedCrossRefGoogle Scholar
  68. Omar, R., Rohrer, J. D., Hailstone, J. C., & Warren, J. D. (2011). Structural neuroanatomy of face processing in frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery & Psychiatry, 82(12), 1341–1343.CrossRefGoogle Scholar
  69. Palermo, R., & Rhodes, G. (2007). Are you always on my mind? A review of how face perception and attention interact. Neuropsychologia, 45(1), 75–92.PubMedCrossRefGoogle Scholar
  70. Palermo, R., Willis, M. L., Rivolta, D., McKone, E., Wilson, C. E., & Calder, A. J. (2011). Impaired holistic coding of facial expression and facial identity in congenital prosopagnosia. Neuropsychologia, 49(5), 1226–1235.PubMedPubMedCentralCrossRefGoogle Scholar
  71. Pascalis, O., & de Schonen, S. (1994). Recognition memory in 3-to 4-day-old human neonates. Neuroreport, 5(14), 1721–1724.PubMedCrossRefGoogle Scholar
  72. Piguet, O., Hornberger, M., Mioshi, E., & Hodges, J. R. (2011). Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management. The Lancet Neurology, 10(2), 162–172.PubMedCrossRefGoogle Scholar
  73. Pitcher, D., Duchaine, B., & Walsh, V. (2014). Combined TMS and fMRI reveal dissociable cortical pathways for dynamic and static face perception. Current Biology, 24(17), 2066–2070.PubMedCrossRefGoogle Scholar
  74. Ranasinghe, K. G., Rankin, K. P., Lobach, I. V., Kramer, J. H., Sturm, V. E., Bettcher, B. M., et al. (2016). Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage. Neurology, 86(7), 600–610.PubMedPubMedCentralCrossRefGoogle Scholar
  75. Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., et al. (2011). Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain, 134(9), 2456–2477.PubMedPubMedCentralCrossRefGoogle Scholar
  76. Ratnavalli, E., Brayne, C., Dawson, K., & Hodges, J. R. (2002). The prevalence of frontotemporal dementia. Neurology, 58(11), 1615–1621.PubMedCrossRefGoogle Scholar
  77. Rhodes, G., Pond, S., Burton, N., Kloth, N., Jeffery, L., Bell, J., et al. (2015). How distinct is the coding of face identity and expression? Evidence for some common dimensions in face space. Cognition, 142, 123–137.PubMedCrossRefGoogle Scholar
  78. Rosen, H. J., Gorno-Tempini, M. L., Goldman, W., Perry, R., Schuff, N., Weiner, M., et al. (2002a). Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Neurology, 58(2), 198–208.PubMedCrossRefGoogle Scholar
  79. Rosen, H. J., Perry, R. J., Murphy, J., Kramer, J. H., Mychack, P., Schuff, N., et al. (2002b). Emotion comprehension in the temporal variant of frontotemporal dementia. Brain, 125(10), 2286–2295.PubMedCrossRefGoogle Scholar
  80. Rosen, H. J., Pace-Savitsky, K., Perry, R. J., Kramer, J. H., Miller, B. L., & Levenson, R. W. (2004). Recognition of emotion in the frontal and temporal variants of frontotemporal dementia. Dementia and Geriatric Cognitive Disorders, 17(4), 277–281.PubMedCrossRefGoogle Scholar
  81. Rossion, B., Dricot, L., Goebel, R., & Busigny, T. (2011). Holistic face categorization in higher order visual areas of the normal and prosopagnosic brain: toward a non-hierarchical view of face perception. Frontiers in Human Neuroscience, 4, 225.PubMedPubMedCentralCrossRefGoogle Scholar
  82. Rossor, M. N., Foxe, N. C., Mummery, C. J., SChott, J. M., & Warren, J. D. (2010). The diagnosis of young-onset dementia. Lancet Neurology, 9(8), 793–806.PubMedPubMedCentralCrossRefGoogle Scholar
  83. Savage, S. A., Piguet, O., & Hodges, J. R. (2014). Giving words new life: generalization of word retraining outcomes in semantic dementia. Journal of Alzheimer's Disease, 40(2), 309–317.PubMedGoogle Scholar
  84. Schiltz, C., & Rossion, B. (2006). Faces are represented holistically in the human occipito-temporal cortex. NeuroImage, 32, 1385–1394.PubMedCrossRefGoogle Scholar
  85. Seeley, W. W., Crawford, R., Rascovsky, K., Kramer, J. H., Weiner, M., Miller, B. L., et al. (2008). Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia. Archives of Neurology, 65(2), 249–255.PubMedPubMedCentralCrossRefGoogle Scholar
  86. Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L., & Greicius, M. D. (2009). Neurodegenerative diseases target large-scale human brain networks. Neuron, 62(1), 42–52.PubMedPubMedCentralCrossRefGoogle Scholar
  87. Simons, J. S., Graham, K. S., Galton, C. J., Patterson, K., & Hodges, J. R. (2001). Semantic knowledge and episodic memory for faces in semantic dementia. Neuropsychology, 15(1), 101.PubMedCrossRefGoogle Scholar
  88. Snowden, J., Bathgate, D., Varma, A., Blackshaw, A., Gibbons, Z., & Neary, D. (2001). Distinct behavioural profiles in frontotemporal dementia and semantic dementia. Journal of Neurology, Neurosurgery & Psychiatry, 70(3), 323–332.CrossRefGoogle Scholar
  89. Snowden, J., Thompson, J., & Neary, D. (2004). Knowledge of famous faces and names in semantic dementia. Brain, 127(4), 860–872.PubMedCrossRefGoogle Scholar
  90. Tranel, D., Damasio, A. R., & Damasio, H. (1988). Intact recognition of facial expression, gender, and age in patients with impaired recognition of face identity. Neurology, 38(5), 690–690.PubMedCrossRefGoogle Scholar
  91. Van den Stock, J., De Winter, F.-L., de Gelder, B., Rangarajan, J. R., Cypers, G., Maes, F., et al. (2015). Impaired recognition of body expressions in the behavioral variant of frontotemporal dementia. Neuropsychologia, 75, 496–504.PubMedCrossRefGoogle Scholar
  92. Virani, K., Jesso, S., Kertesz, A., Mitchell, D., & Finger, E. (2013). Functional neural correlates of emotional expression processing deficits in behavioural variant frontotemporal dementia. Journal of Psychiatry & Neuroscience, 38(3), 174.CrossRefGoogle Scholar
  93. Vuilleumier, P., & Pourtois, G. (2007). Distributed and interactive brain mechanisms during emotion face perception: evidence from functional neuroimaging. Neuropsychologia, 45(1), 174–194.PubMedCrossRefGoogle Scholar
  94. Yin, R. K. (1969). Looking at upside-down faces. Journal of Experimental Psychology, 81(1), 141.CrossRefGoogle Scholar
  95. Young, A. W., Hellawell, D., & Hay, D. C. (1987). Configurational information in face perception. Perception, 16(6), 747–759.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Rosalind Hutchings
    • 1
    • 2
    • 3
  • Romina Palermo
    • 3
    • 4
  • Olivier Piguet
    • 1
    • 2
    • 3
  • Fiona Kumfor
    • 1
    • 2
    • 3
  1. 1.Neuroscience Research AustraliaSydneyAustralia
  2. 2.The School of Medical SciencesUniversity of New South WalesSydneyAustralia
  3. 3.Australia Research Council, Centre of Excellence in Cognition and its DisordersSydneyAustralia
  4. 4.School of PsychologyUniversity of Western AustraliaPerthAustralia

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