Neuropsychology Review

, Volume 17, Issue 4, pp 427–444

Neuropsychological Deficits in Childhood Epilepsy Syndromes

Article

Abstract

Seizure disorders are relatively common in childhood, and the International League Against Epilepsy (ILAE) provides a hierarchical classification system to define seizure types. At the final level of classification, specific epilepsy syndromes are defined that represent a complex of signs and symptoms unique to an epilepsy condition. The present review discusses the issues related to several of these epilepsy syndromes in childhood, including those classified as generalized idiopathic epilepsies (e.g., childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy), focal epilepsies (benign rolandic epilepsy, occipital epilepsy, temporal lobe epilepsy, frontal lobe epilepsy) and the “epileptic encephalopathies,” including Dravet’s Syndrome, West Syndrome, Lennox–Gastaut Syndrome, Myoclonic Astatic Epilepsy, and Landau–Kleffner Syndrome. For each syndrome, the epidemiology, clinical manifestations, treatments, and neuropsychological findings are discussed.

Keywords

Epilepsy Children Syndromes Neuropsychological 

References

  1. Adams, C. B. T., Beardsworth, E. D., Oxbury, S., Oxbury, J., & Fenwick, P. B. C. (1990). Temporal lobectomy in 44 children: Outcome and neuropsychological follow-up. Journal of Epilepsy, 3(Suppl), 157–163.Google Scholar
  2. Appleton, R. E. (2001). West syndrome: Long-term prognosis and social aspects. Brain & Development, 23(7), 688–691.CrossRefGoogle Scholar
  3. Arunkumar, G., Prakash, K., & Rothner, D. (2001). Localization-related epilepsies: Simple partial seizures, complex partial seizures, benign focal epilepsy of childhood, and epilepsia partialis continua. In J. Pellock, W. E. Dodson, & B. Bourgeois (Eds.), (2nd Ed., pp. 243–264). New York: Demos.Google Scholar
  4. Asconape, J., & Penry, J. K. (1984). Some clinical and EEG aspects of benign juvenile myoclonic epilepsy. Epilepsia, 25(1), 108–114.PubMedCrossRefGoogle Scholar
  5. Auclair, L., Jambaque, I., Dulac, O., LaBerge, D., & Sieroff, E. (2005). Deficit of preparatory attention in children with frontal lobe epilepsy. Neuropsychologia, 43(12), 1701–1712.PubMedCrossRefGoogle Scholar
  6. Beardsworth, E. D., & Zaidel, D. W. (1994). Memory for faces in epileptic children before and after brain surgery. Journal of Clinical and Experimental Neuropsychology: Official Journal of the International Neuropsychological Society, 16(4), 589–596.Google Scholar
  7. Bello-Espinosa, L. E., & Roberts, S. L. (2003). Levetiracetam for benign epilepsy of childhood with centrotemporal spikes—Three cases. Seizure, 12(3), 157–159.PubMedCrossRefGoogle Scholar
  8. Benbadis, S. R. (2005). Practical management issues for idiopathic generalized epilepsies. Epilepsia, 46(Suppl 9), 125–132.PubMedCrossRefGoogle Scholar
  9. Beran, R. G., Berkovic, S. F., Dunagan, F. M., Vajda, F. J., Danta, G., Black, A. B., et al. (1998). Double-blind, placebo-controlled, crossover study of lamotrigine in treatment-resistant generalised epilepsy. Epilepsia, 39(12), 1329–1333.PubMedCrossRefGoogle Scholar
  10. Berg, A. T., Levy, S. R., Testa, F. M., & Shinnar, S. (1999). Classification of childhood epilepsy syndromes in newly diagnosed epilepsy: Interrater agreement and reasons for disagreement. Epilepsia, 40(4), 439–444.PubMedCrossRefGoogle Scholar
  11. Berg, A. T., Shinnar, S., Levy, S. R., Testa, F. M., Smith-Rapaport, S., & Beckerman, B. (2000). How well can epilepsy syndromes be identified at diagnosis? A reassessment 2 years after initial diagnosis. Epilepsia, 41(10), 1269–1275.PubMedCrossRefGoogle Scholar
  12. Besag, F. M. (2006). Cognitive and behavioral outcomes of epileptic syndromes: Implications for education and clinical practice. Epilepsia, 47(Suppl 2), 119–125.PubMedCrossRefGoogle Scholar
  13. Billingsley, R., & Smith, M. L. (2000). Intelligence profiles in children and adolescents with left temporal lobe epilepsy: Relationship to language laterality. Brain and Cognition, 43(1–3), 44–49.PubMedGoogle Scholar
  14. Billingsley, R. L., Smith, M. L., & McAndrews, M. P. (2000). Material-specific and non-specific attention deficits in children and adolescents following temporal-lobe surgery. Neuropsychologia, 38(3), 292–303.PubMedCrossRefGoogle Scholar
  15. Bishop, D. V. (1985). Age of onset and outcome in ‘acquired aphasia with convulsive disorder’ (Landau–Kleffner syndrome). Developmental Medicine and Child Neurology, 27(6), 705–712.PubMedCrossRefGoogle Scholar
  16. Bjornaes, H., Stabell, K., Henriksen, O., & Loyning, Y. (2001). The effects of refractory epilepsy on intellectual functioning in children and adults. A longitudinal study. Seizure: The Journal of the British Epilepsy Association, 10(4), 250–259.Google Scholar
  17. Blume, W. T., David, R. B., & Gomez, M. R. (1973). Generalized sharp and slow wave complexes. Associated clinical features and long-term follow-up. Brain: A Journal of Neurology, 96(2), 289–306.Google Scholar
  18. Bourgeois, B. F. (1998). Temporal lobe epilepsy in infants and children. Brain & Development, 20(3), 135–141.CrossRefGoogle Scholar
  19. Bourgeois, B. F. (2000). Drug treatment of benign focal epilepsies of childhood. Epilepsia, 41(8), 1057–1058.PubMedCrossRefGoogle Scholar
  20. Browne, T. R. (1976). Clonazepam. A review of a new anticonvulsant drug. Archives of Neurology, 33(5), 326–332.PubMedGoogle Scholar
  21. Browne, T. R. (1978). Clonazepam. The New England Journal of Medicine, 299(15), 812–816.PubMedCrossRefGoogle Scholar
  22. Browne, T. R., Dreifuss, F. E., Dyken, P. R., Goode, D. J., Penry, J. K., Porter, R. J., et al. (1975). Ethosuximide in the treatment of absence (peptit mal) seizures. Neurology, 25(6), 515–524.PubMedGoogle Scholar
  23. Bruni, J., Wilder, B. J., Bauman, A. W., & Willmore, L. J. (1980). Clinical efficacy and long-term effects of valproic acid therapy on spike-and-wave discharges. Neurology, 30(1), 42–46.PubMedGoogle Scholar
  24. Camfield, P., & Camfield, C. (2002). Epileptic syndromes in childhood: Clinical features, outcomes, and treatment. Epilepsia, 43, 27–32.PubMedCrossRefGoogle Scholar
  25. Camfield, P. R., Gates, R., Ronen, G., Camfield, C., Ferguson, A., & MacDonald, G. W. (1984). Comparison of cognitive ability, personality profile, and school success in epileptic children with pure right versus left temporal lobe EEG foci. Annals of Neurology, 15(2), 122–126.PubMedCrossRefGoogle Scholar
  26. Caraballo, R. H., & Fejerman, N. (2006). Dravet syndrome: A study of 53 patients. Epilepsy Research, 70(Suppl 1), S231–S238.PubMedCrossRefGoogle Scholar
  27. Casse-Perot, C., Wolf, M., & Dravet, C. (2001). Neuropsychological aspects of severe myoclonic epilepsy in infancy. In I. Jambaque, M. Lassonde, & O. Dulac (Eds.), Neuropsychology of childhood epilepsy (pp. 131–140, 1st ed.). New York: Plenum.Google Scholar
  28. Cavazzuti, G. B. (1980). Epidemiology of different types of epilepsy in school age children of Modena, Italy. Epilepsia, 21(1), 57–62.PubMedCrossRefGoogle Scholar
  29. Chaix, Y., Daquin, G., Monteiro, F., Villeneuve, N., Laguitton, V., & Genton, P. (2003). Absence epilepsy with onset before age three years: A heterogeneous and often severe condition. Epilepsia, 44(7), 944–949.PubMedCrossRefGoogle Scholar
  30. Chelune, G. J., Naugle, R. I., Hermann, B. P., Barr, W. B., Trenerry, M. R., Loring, D. W., et al. (1998). Does presurgical IQ predict seizure outcome after temporal lobectomy? Evidence from the Bozeman epilepsy consortium. Epilepsia, 39(3), 314–318.PubMedCrossRefGoogle Scholar
  31. Chilosi, A. M., Brovedani, P., Moscatelli, M., Bonanni, P., & Guerrini, R. (2006). Neuropsychological findings in idiopathic occipital lobe epilepsies. Epilepsia, 47(Suppl 2), 76–78.PubMedCrossRefGoogle Scholar
  32. Clusmann, H., Kral, T., Gleissner, U., Sassen, R., Urbach, H., Blumcke, I., et al. (2004). Analysis of different types of resection for pediatric patients with temporal lobe epilepsy. Neurosurgery, 54(4), 847–859 discussion 859–860.PubMedCrossRefGoogle Scholar
  33. Cohen, M. (1992). Auditory/verbal and visual/spatial memory in children with complex partial epilepsy of temporal lobe origin. Brain and Cognition, 20(2), 315–326.PubMedCrossRefGoogle Scholar
  34. Cohen, H., & Le Normand, M. T. (1998). Language development in children with simple-partial left-hemisphere epilepsy. Brain and Language, 64(3), 409–422.PubMedCrossRefGoogle Scholar
  35. Cohen, M., Prather, A., Town, P., & Hynd, G. (1990). Neurodevelopmental differences in emotional prosody in normal children and children with left and right temporal lobe epilepsy. Brain and Language, 38(1), 122–134.PubMedCrossRefGoogle Scholar
  36. Commission on Classification and Terminology of the International League Against Epilepsy (1981). Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia, 22, 489–501.CrossRefGoogle Scholar
  37. Coppola, G. (2004). Treatment of partial seizures in childhood: An overview. CNS Drugs, 18(3), 133–156.PubMedCrossRefGoogle Scholar
  38. Cowan, L. D. (2002). The epidemiology of the epilepsies in children. Mental Retardation and Developmental Disabilities Research Reviews, 8(3), 171–181.PubMedCrossRefGoogle Scholar
  39. Croona, C., Kihlgren, M., Lundberg, S., Eeg-Olofsson, O., & Eeg-Olofsson, K. E. (1999). Neuropsychological findings in children with benign childhood epilepsy with centrotemporal spikes. Developmental Medicine and Child Neurology, 41(12), 813–818.PubMedCrossRefGoogle Scholar
  40. Cross, J. H. (2002). Topiramate monotherapy for childhood absence seizures: An open label pilot study. Seizure: The Journal of the British Epilepsy Association, 11(6), 406–410.Google Scholar
  41. Culhane-Shelburne, K., Chapieski, L., Hiscock, M., & Glaze, D. (2002). Executive functions in children with frontal and temporal lobe epilepsy. Journal of the International Neuropsychological Society, 8(5), 623–632.PubMedCrossRefGoogle Scholar
  42. Dalby, M. A. (1969). Epilepsy and 3 per second spike and wave rhythms. A clinical, electroencephalographic and prognostic analysis of 346 patients. Acta Neurologica Scandinavica, (Suppl), Suppl 40–40:3+.Google Scholar
  43. de Araujo , G. M., Pascalicchio, T. F., Lin, K., Sousa, P. S., & Yacubian, E. M. T. (2006). Neuropsychiatric profiles of patients with juvenile myoclonic epilepsy treated with valproate or topiramate. Epilepsy & Behavior, 8(3), 606–609.CrossRefGoogle Scholar
  44. Debiais, S., Tuller, L., Barthez, M. A., Monjauze, C., Khomsi, A., Praline, J., et al. (2007). Epilepsy and language development: The continuous spike-waves during slow sleep syndrome. Epilepsia, 48(6), 1104–1110.Google Scholar
  45. Delgado-Escueta, A. V., Greenberg, D. A., Treiman, L., Liu, A., Sparkes, R. S., Barbetti, A., et al. (1989). Mapping the gene for juvenile myoclonic epilepsy. Epilepsia, 30(Suppl 4), S8–S18.PubMedCrossRefGoogle Scholar
  46. Deonna, T. W. (1991). Acquired epileptiform aphasia in children (Landau–Kleffner syndrome). Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society, 8(3), 288–298.Google Scholar
  47. Deonna, T., Peter, C., & Ziegler, A. L. (1989). Adult follow-up of the acquired aphasia-epilepsy syndrome in childhood. report of 7 cases. Neuropediatrics, 20(3), 132–138.PubMedGoogle Scholar
  48. Deonna, T., Ziegler, A. L., Despland, P. A., & van Melle, G. (1986). Partial epilepsy in neurologically normal children: Clinical syndromes and prognosis. Epilepsia, 27(3), 241–247.PubMedCrossRefGoogle Scholar
  49. Devinsky, O., Gershengorn, J., Brown, E., Perrine, K., Vazquez, B., & Luciano, D. (1997). Frontal functions in juvenile myoclonic epilepsy. Neuropsychiatry, Neuropsychology, & Behavioral Neurology, 10(4), 243–246.Google Scholar
  50. Dulac, O., Plouin, P., & Jambaque, I. (1993). Predicting favorable outcome in idiopathic west syndrome. Epilepsia, 34(4), 747–756.PubMedCrossRefGoogle Scholar
  51. Dunn, D. W., & Kronenberger, W. G. (2005). Childhood epilepsy, attention problems, and ADHD: Review and practical considerations. Seminars in Pediatric Neurology, 12(4), 222–228.PubMedCrossRefGoogle Scholar
  52. Eeg-Olofsson, O., Safwenberg, J., & Wigertz, A. (1982). HLA and epilepsy: An investigation of different types of epilepsy in children and their families. Epilepsia, 23(1), 27–34.PubMedCrossRefGoogle Scholar
  53. Engel Jr., J. (2006). ILAE classification of epilepsy syndromes. Epilepsy Research, 70(Suppl 1), S5–S10.PubMedCrossRefGoogle Scholar
  54. Farwell, J. R., Dodrill, C. B., & Batzel, L. W. (1985). Neuropsychological abilities of children with epilepsy. Epilepsia, 26(5), 395–400.PubMedCrossRefGoogle Scholar
  55. Filippini, M., Boni, A., Dazzani, G., Guerra, A., & Gobbi, G. (2006). Neuropsychological findings: Myoclonic astatic epilepsy (MAE) and Lennox–Gastaut syndrome (LGS). Epilepsia, 47(Suppl 2), 56–59.PubMedCrossRefGoogle Scholar
  56. Frank, L. M., Enlow, T., Holmes, G. L., Manasco, P., Concannon, S., Chen, C., et al. (1999). Lamictal (lamotrigine) monotherapy for typical absence seizures in children. Epilepsia, 40(7), 973–979.PubMedCrossRefGoogle Scholar
  57. Freemon, F. R., Douglas, E. F., & Penry, J. K. (1973). Environmental interaction and memory during petit mal (absence) seizures. Pediatrics, 51(5), 911–918.PubMedGoogle Scholar
  58. Gadian, D. G., Isaacs, E. B., Cross, J. H., Connelly, A., Jackson, G. D., King, M. D., et al. (1996). Lateralization of brain function in childhood revealed by magnetic resonance spectroscopy. Neurology, 46(4), 974–977.PubMedGoogle Scholar
  59. Gaily, E., Appelqvist, K., Kantola-Sorsa, E., Liukkonen, E., Kyyronen, P., Sarpola, M., et al. (1999). Cognitive deficits after cryptogenic infantile spasms with benign seizure evolution. Developmental Medicine and Child Neurology, 41(10), 660–664.PubMedCrossRefGoogle Scholar
  60. Germano, E., Gagliano, A., Magazu, A., Sferro, C., Calarese, T., Mannarino, E., et al. (2005). Benign childhood epilepsy with occipital paroxysms: Neuropsychological findings. Epilepsy Research, 64(3), 137–150.PubMedCrossRefGoogle Scholar
  61. Gleissner, U., Kurthen, M., Sassen, R., Kuczaty, S., Elger, C. E., Linke, D. B., et al. (2003). Clinical and neuropsychological characteristics of pediatric epilepsy patients with atypical language dominance. Epilepsy & Behavior, 4(6), 746–752.CrossRefGoogle Scholar
  62. Gleissner, U., Sassen, R., Schramm, J., Elger, C. E., & Helmstaedter, C. (2005). Greater functional recovery after temporal lobe epilepsy surgery in children. Brain: A Journal of Neurology, 128(Pt 12), 2822–2829.Google Scholar
  63. Gloor, P., & Fariello, R. G. (1988). Generalized epilepsy: Some of its cellular mechanisms differ from those of focal epilepsy. Trends in Neurosciences, 11(2), 63–68.PubMedCrossRefGoogle Scholar
  64. Goldsmith, I. L., Zupanc, M. L., & Buchhalter, J. R. (2000). Long-term seizure outcome in 74 patients with Lennox–Gastaut syndrome: Effects of incorporating MRI head imaging in defining the cryptogenic subgroup. Epilepsia, 41(4), 395–399.PubMedCrossRefGoogle Scholar
  65. Grunewald, R. A., Chroni, E., & Panayiotopoulos, C. P. (1992). Delayed diagnosis of juvenile myoclonic epilepsy. Journal of Neurology, Neurosurgery, and Psychiatry, 55(6), 497–499.PubMedGoogle Scholar
  66. Gulgonen, S., Demirbilek, V., Korkmaz, B., Dervent, A., & Townes, B. D. (2000). Neuropsychological functions in idiopathic occipital lobe epilepsy. Epilepsia, 41(4), 405–411.PubMedCrossRefGoogle Scholar
  67. Gunduz, E., Demirbilek, V., & Korkmaz, B. (1999). Benign rolandic epilepsy: Neuropsychological findings. Seizure: The Journal of the British Epilepsy Association, 8(4), 246–249.Google Scholar
  68. Guzzetta, F. (2006). Cognitive and behavioral outcome in west syndrome. Epilepsia, 47(Suppl 2), 49–52.PubMedCrossRefGoogle Scholar
  69. Guzzetta, F., Frisone, M. F., Ricci, D., Rando, T., & Guzzetta, A. (2002). Development of visual attention in West syndrome. Epilepsia, 43(7), 757–763.PubMedCrossRefGoogle Scholar
  70. Hauser, W. A., Annegers, J. F., & Rocca, W. A. (1996). Descriptive epidemiology of epilepsy: Contributions of population-based studies from Rochester, Minnesota. Mayo Clinic Proceedings. Mayo Clinic, 71(6), 576–586.PubMedGoogle Scholar
  71. Heijbel, J., Blom, S., & Bergfors, P. G. (1975). Benign epilepsy of children with centrotemporal EEG foci. A study of incidence rate in outpatient care. Epilepsia, 16(5), 657–664.PubMedCrossRefGoogle Scholar
  72. Hermann, B., Hansen, R., Seidenberg, M., Magnotta, V., & O’Leary, D. (2003). Neurodevelopmental vulnerability of the corpus callosum to childhood onset localization-related epilepsy. NeuroImage, 18(2), 284–292.PubMedCrossRefGoogle Scholar
  73. Hermann, B. P., Seidenberg, M., & Bell, B. (2002). The neurodevelopmental impact of childhood onset temporal lobe epilepsy on brain structure and function and the risk of progressive cognitive effects. Progress in Brain Research, 135, 429–438.PubMedGoogle Scholar
  74. Hermann, B. P., Seidenberg, M., Haltiner, A., & Wyler, A. R. (1995). Relationship of age at onset, chronologic age, and adequacy of preoperative performance to verbal memory change after anterior temporal lobectomy. Epilepsia, 36(2), 137–145.PubMedCrossRefGoogle Scholar
  75. Hernandez, M. T., Sauerwein, H. C., de Guise, E., Lortie, A., Jambaque, I., Dulac, O., et al. (2001). Neuropsychology of frontal lobe epilepsy in children. In I. Jambaque, M. Lassonde, & O. Dulac (Eds.), Neuropsychology of childhood epilepsy (pp. 103–111, 1st ed.). New York: Plenum.Google Scholar
  76. Hernandez, M. T., Sauerwein, H. C., Jambaque, I., De Guise, E., Lussier, F., Lortie, A., et al. (2002). Deficits in executive functions and motor coordination in children with frontal lobe epilepsy. Neuropsychologia, 40(4), 384–400.PubMedCrossRefGoogle Scholar
  77. Hernandez, M. T., Sauerwein, H. C., Jambaque, I., de Guise, E., Lussier, F., Lortie, A., et al. (2003). Attention, memory, and behavioral adjustment in children with frontal lobe epilepsy. Epilepsy & Behavior, 4(5), 522–536.CrossRefGoogle Scholar
  78. Hurst, D. L. (1990). Epidemiology of severe myoclonic epilepsy of infancy. Epilepsia, 31(4), 397–400.PubMedCrossRefGoogle Scholar
  79. Igarashi, K., Oguni, H., Osawa, M., Awaya, Y., Kato, M., Mimura, M., et al. (2002). Wisconsin card sorting test in children with temporal lobe epilepsy. Brain & Development, 24(3), 174–178.CrossRefGoogle Scholar
  80. Igarashi, K., Oguni, H., Uehara, T., Mukahira, K., & Osawa, M. (1995). Neuropsychological study of localization-related epilepsy in children. Psychiatry and Clinical Neurosciences, 49(3), S270–S272.PubMedCrossRefGoogle Scholar
  81. Jambaque, I. (2001). Neuropsychology of temporal lobe epilepsy in children. In I. Jambaque, M. Lassonde, & O. Dulac (Eds.), Neuropsychology of childhood epilepsy (pp. 97–102, 1st ed.). New York: Plenum.Google Scholar
  82. Jambaque, I., Chiron, C., Dulac, O., Raynaud, C., & Syrota, P. (1993). Visual inattention in West syndrome: A neuropsychological and neurofunctional imaging study. Epilepsia, 34(4), 692–700.PubMedCrossRefGoogle Scholar
  83. Jambaque, I., Dellatolas, G., Dulac, O., Ponsot, G., & Signoret, J. L. (1993). Verbal and visual memory impairment in children with epilepsy. Neuropsychologia, 31(12), 1321–1337.PubMedCrossRefGoogle Scholar
  84. Jambaque, I., Dellatolas, G., Fohlen, M., Bulteau, C., Watier, L., Dorfmuller, G., et al. (2007). Memory functions following surgery for temporal lobe epilepsy in children. Neuropsychologia, 45(12), 2850–2862.Google Scholar
  85. Janz, D. (1985). Epilepsy with impulsive petit mal (juvenile myoclonic epilepsy). Acta Neurologica Scandinavica, 72(5), 449–459.PubMedCrossRefGoogle Scholar
  86. Kaminska, A., Ickowicz, A., Plouin, P., Bru, M. F., Dellatolas, G., & Dulac, O. (1999). Delineation of cryptogenic Lennox–Gastaut syndrome and myoclonic astatic epilepsy using multiple correspondence analysis. Epilepsy Research, 36(1), 15–29.PubMedCrossRefGoogle Scholar
  87. Keene, D. L., Loy-English, I., & Ventureyra, E. C. (1998a). Long-term socioeconomic outcome following surgical intervention in the treatment of refractory epilepsy in childhood and adolescence. Child’s Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery, 14(8), 362–365.Google Scholar
  88. Keene, D. L., Loy-English, I., & Ventureyra, E. C. (1998b). Patient satisfaction with surgical treatment of refractory epilepsy done in childhood and early adolescence. Child’s Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery, 14(1–2), 30–32.Google Scholar
  89. Kieffer-Renaux, V., Kaminska, A., & Dulac, O. (2001). Cognitive deterioration in Lennox–Gastaut and Doose epilepsy. In I. Jambaque, M. Lassonde, & O. Dulac (Eds.), Neuropsychology of childhood epilepsy (pp. 185–190, 1st ed.). New York: Kluwer.Google Scholar
  90. Klein, S. K., Tuchman, R. F., & Rapin, I. (2000). The influence of premorbid language skills and behavior on language recovery in children with verbal auditory agnosia. Journal of Child Neurology, 15(1), 36–43.PubMedGoogle Scholar
  91. Koo, B., Hwang, P. A., & Logan, W. J. (1993). Infantile spasms: Outcome and prognostic factors of cryptogenic and symptomatic groups. Neurology, 43(11), 2322–2327.PubMedGoogle Scholar
  92. Kramer, U., Nevo, Y., Neufeld, M. Y., Fatal, A., Leitner, Y., & Harel, S. (1998). Epidemiology of epilepsy in childhood: A cohort of 440 consecutive patients. Pediatric Neurology, 18(1), 46–50.PubMedCrossRefGoogle Scholar
  93. Kuehn, S. M., Keene, D. L., Richards, P. M., & Ventureyra, E. C. (2002). Are there changes in intelligence and memory functioning following surgery for the treatment of refractory epilepsy in childhood? Child’s Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery, 18(6–7), 306–310.Google Scholar
  94. Landau, W. M., & Kleffner, F. R. (1957). Syndrome of acquired aphasia with convulsive disorder in children. Neurology, 7(8), 523–530.PubMedGoogle Scholar
  95. Lee, G. P., Westerveld, M., Blackburn, L. B., Park, Y. D., & Loring, D. W. (2005). Prediction of verbal memory decline after epilepsy surgery in children: Effectiveness of Wada memory asymmetries. Epilepsia, 46(1), 97–103.PubMedCrossRefGoogle Scholar
  96. Lendt, M., Gleissner, U., Helmstaedter, C., Sassen, R., Clusmann, H., & Elger, C. E. (2002). Neuropsychological outcome in children after frontal lobe epilepsy surgery. Epilepsy and Behavior, 3(1), 51–59.PubMedCrossRefGoogle Scholar
  97. Lendt, M., Helmstaedter, C., & Elger, C. E. (1999). Pre- and postoperative neuropsychological profiles in children and adolescents with temporal lobe epilepsy. Epilepsia, 40(11), 1543–1550.PubMedCrossRefGoogle Scholar
  98. Livingston, S., Torres, I., Pauli, L. L., & Rider, R. V. (1965). Petit mal epilepsy. Results of a prolonged follow-up study of 117 patients. JAMA: The Journal of the American Medical Association, 194(3), 227–232.CrossRefGoogle Scholar
  99. Loiseau, P., Duche, B., & Pedespan, J. M. (1995). Absence epilepsies. Epilepsia, 36(12), 1182–1186.PubMedCrossRefGoogle Scholar
  100. Lund, M., & Trolle, E. (1973). Clonazepam in the treatment of epilepsy. Acta Neurologica Scandinavica. Supplementum, 53, 82–90.PubMedGoogle Scholar
  101. Majoie, H. J., Berfelo, M. W., Aldenkamp, A. P., Evers, S. M., Kessels, A. G., & Renier, W. O. (2001). Vagus nerve stimulation in children with therapy-resistant epilepsy diagnosed as Lennox–Gastaut syndrome: Clinical results, neuropsychological effects, and cost-effectiveness. Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society, 18(5), 419–428.Google Scholar
  102. Majoie, H. J., Berfelo, M. W., Aldenkamp, A. P., Renier, W. O., & Kessels, A. G. (2005). Vagus nerve stimulation in patients with catastrophic childhood epilepsy, a 2-year follow-up study. Seizure: The Journal of the British Epilepsy Association, 14(1), 10–18.Google Scholar
  103. Manford, M., Hart, Y. M., Sander, J. W., & Shorvon, S. D. (1992). The national general practice study of epilepsy. The syndromic classification of the international league against epilepsy applied to epilepsy in a general population. Archives of Neurology, 49(8), 801–808.PubMedGoogle Scholar
  104. Matsumoto, A., Watanabe, K., Negoro, T., Sugiura, M., Iwase, K., Hara, K., et al. (1981). Infantile spasms: Etiological factors, clinical aspects, and long term prognosis in 200 cases. European Journal of Pediatrics, 135(3), 239–244.PubMedCrossRefGoogle Scholar
  105. McVicar, K. A., & Shinnar, S. (2004). Landau–Kleffner syndrome, electrical status epilepticus in slow wave sleep, and language regression in children. Mental retardation and developmental disabilities research reviews, 10(2), 144–149.PubMedCrossRefGoogle Scholar
  106. Meletti, S., Benuzzi, F., Nichelli, P., & Tassinaria, C. A. (2003). Damage to the right hippocampal-amygdala formation during early infancy and recognition of fearful faces: Neuropsychological and fMRI evidence in subjects with temporal lobe epilepsy. Annals of the New York Academy of Sciences, 1000, 385–388.PubMedCrossRefGoogle Scholar
  107. Metrakos, K., & Metrakos, J. D. (1961). Genetics of convulsive disorders. II. Genetic and electroencephalographic studies in centrencephalic epilepsy. Neurology, 11, 474–483.PubMedGoogle Scholar
  108. Nabbout, R., & Dulac, O. (2003). Epileptic encephalopathies: A brief overview. Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society, 20(6), 393–397.Google Scholar
  109. Neubauer, B. A., Fiedler, B., Himmelein, B., Kampfer, F., Lassker, U., Schwabe, G., et al. (1998). Centrotemporal spikes in families with rolandic epilepsy: Linkage to chromosome 15q14. Neurology, 51(6), 1608–1612.PubMedGoogle Scholar
  110. Nolan, M. A., Redoblado, M. A., Lah, S., Sabaz, M., Lawson, J. A., Cunningham, A. M., et al. (2003). Intelligence in childhood epilepsy syndromes. Epilepsy Research, 53(1–2), 139–150.PubMedCrossRefGoogle Scholar
  111. Nolan, M. A., Redoblado, M. A., Lah, S., Sabaz, M., Lawson, J. A., Cunningham, A. M., et al. (2004). Memory function in childhood epilepsy syndromes. Journal of Paediatrics and Child Health, 40(1–2), 20–27.PubMedCrossRefGoogle Scholar
  112. Northcott, E., Connolly, A. M., Berroya, A., Sabaz, M., McIntyre, J., Christie, J., et al. (2005). The neuropsychological and language profile of children with benign rolandic epilepsy. Epilepsia, 46(6), 924–930.PubMedCrossRefGoogle Scholar
  113. Northcott, E., Connolly, A. M., Mclntyre, J., Christie, J., Berroya, A., Taylor, A., et al. (2006). Longitudinal assessment of neuropsychologic and language function in children with benign rolandic epilepsy. Journal of Child Neurology, 21(6), 518–522.PubMedGoogle Scholar
  114. Oguni, H., Hayashi, K., & Osawa, M. (1996). Long-term prognosis of Lennox–Gastaut syndrome. Epilepsia, 37(Suppl 3), 44–47.PubMedCrossRefGoogle Scholar
  115. Oguni, H., Hayashi, K., Osawa, M., Awaya, Y., Fukuyama, Y., Fukuma, G., et al. (2005). Severe myoclonic epilepsy in infancy: Clinical analysis and relation to SCN1A mutations in a Japanese cohort. Advances in Neurology, 95, 103–117.PubMedGoogle Scholar
  116. Oguni, H., Mukahira, K., Tanaka, T., Awaya, Y., Saito, K., Shimizu, H., et al. (2000). Surgical indication for refractory childhood epilepsy. Epilepsia, 41(Suppl 9), 21–25.PubMedCrossRefGoogle Scholar
  117. Oguni, H., Tanaka, T., Hayashi, K., Funatsuka, M., Sakauchi, M., Shirakawa, S., et al. (2002). Treatment and long-term prognosis of myoclonic-astatic epilepsy of early childhood. Neuropediatrics, 33(3), 122–132.PubMedCrossRefGoogle Scholar
  118. Ohtsuka, Y., Maniwa, S., Ogino, T., Yamatogi, Y., & Ohtahara, S. (1991). Severe myoclonic epilepsy in infancy: A long-term follow-up study. The Japanese Journal of Psychiatry and Neurology, 45(2), 416–418.PubMedGoogle Scholar
  119. Panayiotopoulos, C. P., Tahan, R., & Obeid, T. (1991). Juvenile myoclonic epilepsy: Factors of error involved in the diagnosis and treatment. Epilepsia, 32(5), 672–676.PubMedCrossRefGoogle Scholar
  120. Pascalicchio, T. F., de Araujo Filho, G. M., da Silva Noffs, M. H., Lin, K., Caboclo, L. O. S. F., Vidal-Dourado, M., et al. (2007). Neuropsychological profile of patients with juvenile myoclonic epilepsy: A controlled study of 50 patients. Epilepsy & Behavior, 10(2), 263–267.CrossRefGoogle Scholar
  121. Pavone, P., Bianchini, R., Trifiletti, R. R., Incorpora, G., Pavone, A., & Parano, E. (2001). Neuropsychological assessment in children with absence epilepsy. Neurology, 56(8), 1047–1051.PubMedGoogle Scholar
  122. Perini, G. I., Tosin, C., Carraro, C., Bernasconi, G., Canevini, M. P., Canger, R., et al. (1996). Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy. Journal of Neurology, Neurosurgery, and Psychiatry, 61(6), 601–605.PubMedGoogle Scholar
  123. Plaza, M., Rigoard, M. T., Chevrie-Muller, C., Cohen, H., & Picard, A. (2001). Short-term memory impairment and unilateral dichotic listening extinction in a child with Landau–Kleffner syndrome: Auditory or phonological disorder? Brain and Cognition, 46(1–2), 235–240.PubMedCrossRefGoogle Scholar
  124. Prevost, J., Lortie, A., Nguyen, D., Lassonde, M., & Carmant, L. (2006). Nonlesional frontal lobe epilepsy (FLE) of childhood: Clinical presentation, response to treatment and comorbidity. Epilepsia, 47(12), 2198–2201.PubMedCrossRefGoogle Scholar
  125. Rando, T., Bancale, A., Baranello, G., Bini, M., De Belvis, A. G., Epifanio, R., et al. (2004). Visual function in infants with west syndrome: Correlation with EEG patterns. Epilepsia, 45(7), 781–786.PubMedCrossRefGoogle Scholar
  126. Rando, T., Baranello, G., Ricci, D., Guzzetta, A., Tinelli, F., Biagioni, E., et al. (2005). Cognitive competence at the onset of west syndrome: Correlation with EEG patterns and visual function. Developmental Medicine and Child Neurology, 47(11), 760–765.PubMedCrossRefGoogle Scholar
  127. Reutens, D. C., & Berkovic, S. F. (1995). Idiopathic generalized epilepsy of adolescence: Are the syndromes clinically distinct? Neurology, 45(8), 1469–1476.PubMedGoogle Scholar
  128. Riikonen, R. (2001). Long-term outcome of patients with West syndrome. Brain & Development, 23(7), 683–687.CrossRefGoogle Scholar
  129. Riva, D., Avanzini, G., Franceschetti, S., Nichelli, F., Saletti, V., Vago, C., et al. (2005). Unilateral frontal lobe epilepsy affects executive functions in children. Neurological Sciences: Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 26(4), 263–270.Google Scholar
  130. Robinson, R. O., Baird, G., Robinson, G., & Simonoff, E. (2001). Landau–Kleffner syndrome: Course and correlates with outcome. Developmental medicine and child neurology, 43(4), 243–247.PubMedCrossRefGoogle Scholar
  131. Robinson, S., Park, T. S., Blackburn, L. B., Bourgeois, B. F., Arnold, S. T., & Dodson, W. E. (2000). Transparahippocampal selective amygdalohippocampectomy in children and adolescents: Efficacy of the procedure and cognitive morbidity in patients. Journal of Neurosurgery, 93(3), 402–409.PubMedGoogle Scholar
  132. Rotenberg, J., & Pearl, P. L. (2003). Landau–Kleffner syndrome. Archives of Neurology, 60(7), 1019–1021.PubMedCrossRefGoogle Scholar
  133. Scheffer, I. E., Wallace, R., Mulley, J. C., & Berkovic, S. F. (2001). Clinical and molecular genetics of myoclonic-astatic epilepsy and severe myoclonic epilepsy in infancy (Dravet syndrome). Brain & Development, 23(7), 732–735.CrossRefGoogle Scholar
  134. Scholtes, F. B., Hendriks, M. P., & Renier, W. O. (2005). Cognitive deterioration and electrical status epilepticus during slow sleep. Epilepsy & Behavior, 6(2), 167–173.CrossRefGoogle Scholar
  135. Schubert, R. (2005). Attention deficit disorder and epilepsy. Pediatric Neurology, 32(1), 1–10.PubMedCrossRefGoogle Scholar
  136. Seidel, W. T., & Mitchell, W. G. (1999). Cognitive and behavioral effects of carbamazepine in children: Data from benign rolandic epilepsy. Journal of Child Neurology, 14(11), 716–723.PubMedGoogle Scholar
  137. Sherard Jr., E. S., Steiman, G. S., & Couri, D. (1980). Treatment of childhood epilepsy with valproic acid: Results of the first 100 patients in a 6-month trial. Neurology, 30(1), 31–35.PubMedGoogle Scholar
  138. Sidenvall, R., Forsgren, L., Blomquist, H. K., & Heijbel, J. (1993). A community-based prospective incidence study of epileptic seizures in children. Acta Paediatrica (Oslo, Norway: 1992), 82(1), 60–65.Google Scholar
  139. Siren, A., Kylliainen, A., Tenhunen, M., Hirvonen, K., Riita, T., & Koivikko, M. (2007). Beneficial effects of antiepileptic medication on absence seizures and cognitive functioning in children. Epilepsy and Behavior, 11(1), 85–91.Google Scholar
  140. Stephani, U. (2006). The natural history of myoclonic astatic epilepsy (Doose syndrome) and Lennox–Gastaut syndrome. Epilepsia, 47(Suppl 2), 53–55.PubMedCrossRefGoogle Scholar
  141. Sveinbjornsdottir, S., & Duncan, J. S. (1993). Parietal and occipital lobe epilepsy: A review. Epilepsia, 34(3), 493–521.PubMedCrossRefGoogle Scholar
  142. Szabo, C. A., Wyllie, E., Stanford, L. D., Geckler, C., Kotagal, P., Comair, Y. G., et al. (1998). Neuropsychological effect of temporal lobe resection in preadolescent children with epilepsy. Epilepsia, 39(8), 814–819.PubMedCrossRefGoogle Scholar
  143. Takeoka, M., Riviello Jr., J. J., Duffy, F. H., Kim, F., Kennedy, D. N., Makris, N., et al. (2004). Bilateral volume reduction of the superior temporal areas in Landau–Kleffner syndrome. Neurology, 63(7), 1289–1292.PubMedGoogle Scholar
  144. Tassinari, C. A., Rubboli, G., Volpi, L., Meletti, S., d’Orsi, G., Franca, M., et al. (2000). Encephalopathy with electrical status epilepticus during slow sleep or ESES syndrome including the acquired aphasia. Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology, 111(Suppl 2), S94–S102.Google Scholar
  145. Tovia, E., Goldberg-Stern, H., Shahar, E., & Kramer, U. (2006). Outcome of children with juvenile absence epilepsy. Journal of Child Neurology, 21(9), 766–768.PubMedCrossRefGoogle Scholar
  146. Trinka, E., Kienpointner, G., Unterberger, I., Luef, G., Bauer, G., Doering, L. B., et al. (2006). Psychiatric comorbidity in juvenile myoclonic epilepsy. Epilepsia, 47(12), 2086–2091.PubMedCrossRefGoogle Scholar
  147. Vadlamudi, L., Kjeldsen, M. J., Corey, L. A., Solaas, M. H., Friis, M. L., Pellock, J. M., et al. (2006). Analyzing the etiology of benign rolandic epilepsy: A multicenter twin collaboration. Epilepsia, 47(3), 550–555.PubMedCrossRefGoogle Scholar
  148. Vanasse, C. M., Beland, R., Carmant, L., & Lassonde, M. (2005). Impact of childhood epilepsy on reading and phonological processing abilities. Epilepsy & Behavior, 7(2), 288–296.CrossRefGoogle Scholar
  149. Van Hout, A. (2001). Aphasia and auditory agnosia in children with Landau–Kleffner syndrome. In I. Jambaque, M. Lassonde, & O. Dulac (Eds.), Neuropsychology of childhood epilepsy (pp. 191–198, 1st ed.). New York: Kluwer.Google Scholar
  150. Vazquez, B., Devinsky, O., Luciano, D., Alper, K., & Perrine, K. (1993). Juvenile myoclonic epilepsy: Clinical features and factors related to misdiagnosis. Journal of Epilepsy, 6(4), 233–238.CrossRefGoogle Scholar
  151. Veggiotti, P., Termine, C., Granocchio, E., Bova, S., Papalia, G., & Lanzi, G. (2002). Long-term neuropsychological follow-up and nosological considerations in five patients with continuous spikes and waves during slow sleep. Epileptic Disorders: International Epilepsy Journal with Videotape, 4(4), 243–249.Google Scholar
  152. Westerveld, M., Sass, K. J., Chelune, G. J., Hermann, B. P., Barr, W. B., Loring, D. W., et al. (2000). Temporal lobectomy in children: Cognitive outcome. Journal of Neurosurgery, 92(1), 24–30.PubMedCrossRefGoogle Scholar
  153. Williams, J., Griebel, M. L., Sharp, G. B., & Boop, F. A. (1998). Cognition and behavior after temporal lobectomy in pediatric patients with intractable epilepsy. Pediatric Neurology, 19(3), 189–194.PubMedCrossRefGoogle Scholar
  154. Williams, J., Sharp, G., Bates, S., & Griebel, M. (1996). Academic achievement and behavioral ratings in children with absence and complex partial epilepsy. Education & Treatment of Children, 19(2), 143–152.Google Scholar
  155. Wirrell, E. C. (2003). Natural history of absence epilepsy in children. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques, 30(3), 184–188.PubMedGoogle Scholar
  156. Wirrell, E. C., Camfield, C. S., Camfield, P. R., Dooley, J. M., Gordon, K. E., & Smith, B. (1997). Long-term psychosocial outcome in typical absence epilepsy. Sometimes a wolf in sheeps’ clothing. Archives of Pediatrics & Adolescent Medicine, 151(2), 152–158.Google Scholar
  157. Wirrell, E. C., Camfield, C. S., Camfield, P. R., Gordon, K. E., & Dooley, J. M. (1996). Long-term prognosis of typical childhood absence epilepsy: Remission or progression to juvenile myoclonic epilepsy. Neurology, 47(4), 912–918.PubMedGoogle Scholar
  158. Wirrell, E., Farrell, K., & Whiting, S. (2005). The epileptic encephalopathies of infancy and childhood. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques, 32(4), 409–418.PubMedGoogle Scholar
  159. Wolf, P., & Goosses, R. (1986). Relation of photosensitivity to epileptic syndromes. Journal of Neurology, Neurosurgery, and Psychiatry, 49(12), 1386–1391.PubMedGoogle Scholar
  160. Wolff, M., Casse-Perrot, C., & Dravet, C. (2006). Severe myoclonic epilepsy of infants (Dravet syndrome): Natural history and neuropsychological findings. Epilepsia, 47(Suppl 2), 45–48.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.New York University Comprehensive Epilepsy CenterNew YorkUSA

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