The Role of Vesicle Trafficking and Release in Oligodendrocyte Biology

  • Cory R. ReiterEmail author
  • Ernesto R. BongarzoneEmail author
Original Paper


Oligodendrocytes are a subtype of glial cells found within the central nervous system (CNS), responsible for the formation and maintenance of specialized myelin membranes which wrap neuronal axons. The development of myelin requires tight coordination for the cell to deliver lipid and protein building blocks to specific myelin segments at the right time. Both internal and external cues control myelination, thus the reception of these signals also requires precise regulation. In late years, a growing body of evidence indicates that oligodendrocytes, like many other cell types, may use extracellular vesicles (EVs) as a medium for transferring information. The field of EV research has expanded rapidly over the past decade, with new contributions that suggest EVs might have direct involvement in communications with neurons and other glial cells to fine tune oligodendroglial function. This functional role of EVs might also be maladaptive, as it has likewise been implicated in the spreading of toxic molecules within the brain during disease. In this review we will discuss the field’s current understanding of extracellular vesicle biology within oligodendrocytes, and their contribution to physiologic and pathologic conditions.


Exosomes Microvesicles Extracellular vesicles Sphingolipids Myelin Oligodendrocytes Axon-glial communication Demyelination Remyelination 



This work was supported in part by the generous contribution of the Legacy of Angels Foundation, National Institute of Neurological Disorders and Stroke of the National Institutes of Health (R01NS065808) and Dr. Ralph and Marian Falk Medical Research Trust to E.R.B. (Catalyst Award).


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Authors and Affiliations

  1. 1.Department of Anatomy and Cell Biology, College of MedicineUniversity of Illinois at ChicagoChicagoUSA

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