MicroRNAs and Regeneration in Animal Models of CNS Disorders

  • Tamara RoitbakEmail author
Original Paper


microRNAs (miRNAs) are recently identified small RNA molecules that regulate gene expression and significantly influence the essential cellular processes associated with CNS repair after trauma and neuropathological conditions including stroke and neurodegenerative disorders. A number of specific miRNAs are implicated in regulating the development and propagation of CNS injury, as well as its subsequent regeneration. The review focuses on the functions of the miRNAs and their role in brain recovery following CNS damage. The article introduces a brief description of miRNA biogenesis and mechanisms of miRNA-induced gene suppression, followed by an overview of miRNAs involved in the processes associated with CNS repair, including neuroprotection, neuronal plasticity and axonal regeneration, vascular reorganization, neuroinflammation, and endogenous stem cell activation. Specific emphasis is placed on the role of multifunctional miRNA miR-155, as it appears to be involved in multiple neurorestorative processes during different CNS pathologies. In association with our own studies on miR-155, I introduce a new and unexplored approach to cerebral regeneration: regulation of brain tissue repair through a direct modulation of specific miRNA activity. The review concludes with discussion on the challenges and the future potential of miRNA-based therapeutic approaches to CNS repair.


MicroRNA MiR-155 Neurorestoration Post-stroke inflammation Cerebral blood flow Functional recovery 



Neurite outgrowth inhibitor


Transforming growth factor beta


Vascular endothelial growth factor


Cadherin-vascular endothelial cadherin


Traumatic brain injury


Ras homolog enriched in brain


Mammalian target of rapamycin


Rapamycin-insensitive companion of mammalian target of rapamycin


CCAAT/enhancer-binding protein beta


Bone morphogenetic protein


Nitric oxide


Janus kinase


Signal transducers and activators of transcription


Suppressor of cytokine signaling


Src homology 2 (SH2) domain-containing protein-tyrosine phosphatase





This work was supported by the National Institute of Neurological Disorders and Stroke-NIH R01NS082225 Grant.

Compliance with Ethical Standards

Conflict of interest

The author declares no competing financial interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryUniversity of New Mexico Health Sciences CenterAlbuquerqueUSA

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