Neurochemical Research

, Volume 42, Issue 6, pp 1787–1794 | Cite as

Role of Cell Metabolism and Mitochondrial Function During Adult Neurogenesis

Original Paper
First Online:
Received:
Revised:
Accepted:

Abstract

Brain is the major consumer of glucose in the human body, whose pattern of consumption changes through lifetime, decreasing during adolescence up to adulthood. This evidence leads to the hypothesis that, in cerebral developmental stages, glycolysis might be the driving force for the high-energy requirement. Furthermore, several studies claim that neurogenesis process is accompanied by a shift into mitochondrial oxidative metabolism. Herein, we discuss recent work about cell metabolism during neuronal differentiation process, in particular the mitochondrial role in cellular bioenergy dynamics.

Keywords

Neurogenesis Neuronal differentiation Mitochondria Glycolysis Oxidative phosphorylation Oxygen levels 
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Notes

Acknowledgements

The funding was provided by Fundação para a Ciência e a Tecnologia (Grant Nos. ANR/NEU-NMC/0022/2012, IF/00185/2012, SFRH/BD/78440/2011).

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© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.CEDOC, NOVA Medical School/Faculdade de Ciência MédicasUniversidade Nova de LisboaLisboaPortugal
  2. 2.Instituto de Tecnologia Química e Biológica (ITQB)Universidade Nova de LisboaOeirasPortugal
  3. 3.Instituto de Biologia Experimental e Tecnológica (iBET)OeirasPortugal

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