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Neurochemical Research

, Volume 41, Issue 6, pp 1401–1409 | Cite as

Gastrodin Attenuates Cognitive Deficits Induced by 3,3′-Iminodipropionitrile

  • Xiaona Wang
  • Peng Li
  • Jingsheng Liu
  • Xunbo Jin
  • Lianjun Li
  • Dong ZhangEmail author
  • Peng SunEmail author
Original Paper

Abstract

3,3′-Iminodipropionitrile (IDPN), one of the nitrile derivatives, can induce persistent neurotoxicity, and therefore cause dyskinesia and cognitive impairments. Gastrodin, a main bioactive ingredient of Gastrodia elata Blume, is shown to greatly improve cognitive function. The aim of this study was to further determine whether administration of gastrodin can ameliorate IDPN-induced cognitive deficits in the Morris water maze (MWM) and novel object recognition (NOR) task, and to explore the underlying mechanisms. Results showed that exposure to IDPN (100 mg/kg/day, for 8 days) significantly impaired spatial and object recognition memory and that repeated treatment with gastrodin (150 mg/kg/day, for 6 weeks) could effectively alleviate the IDPN-induced cognitive impairments as indicated by increased spatial memory and discrimination ratio in the MWM and NOR tests. Gastrodin treatment also reverted IDPN-induced decreases of γ-aminobutyric acid (GABA) levels and increases of a2 GABAA receptor protein expression in the prefrontal cortex and hippocampus of IDPN-treated rats. These results suggest that gastrodin treatment may provide a novel pharmacological strategy for IDPN-induced cognitive deficits, which was mediated, at least in part, by normalizing the GABAergic system.

Keywords

Gastrodin 3,3′-Iminodipropionitrile Cognitive deficits γ-Aminobutyric acid a2 GABAA receptor 

Notes

Acknowledgments

This work was supported by the Natural Science Foundation of Shandong Province (ZR2015HQ002), Medical and Health Technology Development Program of Shandong Province (2014WS0091), Key Research and Development Plan of Shandong Province (2015GSF118096) and National Natural Science Foundation of China (81572534).

Compliance with Ethical Standards

Conflict of interest

The authors declare that there are no conflicts of interest.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Institute of PhysiologyShandong University School of MedicineJinanPeople’s Republic of China
  2. 2.Minimally Invasive Urology Center, Shandong Provincial Hospital Affiliated to Shandong UniversityShandong University School of MedicineJinanPeople’s Republic of China
  3. 3.Department of Urology, North China Petroleum Administration Bureau General HospitalShandong University School of MedicineRenqiuPeople’s Republic of China

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