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Neurochemical Research

, Volume 40, Issue 7, pp 1520–1525 | Cite as

Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2

  • Yang Li
  • Ou Lv
  • Fenggang Zhou
  • Qingsong Li
  • Zhichao Wu
  • Yongri Zheng
Original Paper

Abstract

Linalool, a natural compound of the essential oils, has been reported to have anti-inflammatory effects. This study aimed to investigate the anti-inflammatory effects and mechanism of linalool in LPS-stimulated BV2 microglia cells. BV2 microglia cells were stimulated with LPS in the presence or absence of linalool. The production of inflammatory mediators TNF-α, IL-1β, NO, and PGE2 as well as Nrf2, HO-1 expression were detected. Our results showed that linalool inhibited LPS-induced TNF-α, IL-1β, NO, and PGE2 production in a dose-dependent manner. Linalool also inhibited LPS-induced NF-κB activation. Treatment of linalool induced nuclear translocation of Nrf2 and expression of HO-1. In addition, our results showed that the anti-inflammatory effect of linalool was attenuated by transfection with Nrf2 siRNA. In conclusion, these results suggested that linalool inhibits LPS-induced inflammation in BV2 microglia cells by activating Nrf2/HO-1 signaling pathway.

Keywords

Linalool LPS Inflammatory mediators Nrf2 

Notes

Conflict of interest

All authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Yang Li
    • 1
  • Ou Lv
    • 2
  • Fenggang Zhou
    • 1
  • Qingsong Li
    • 1
  • Zhichao Wu
    • 1
  • Yongri Zheng
    • 1
  1. 1.Department of NeurosurgeryThe Second Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Department of NeorologyThe Second Affiliated Hospital of Harbin Medical UniversityHarbinChina

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