Neurochemical Research

, Volume 40, Issue 7, pp 1333–1340 | Cite as

Brain Glycogen Decreases During Intense Exercise Without Hypoglycemia: The Possible Involvement of Serotonin

  • Takashi Matsui
  • Shingo Soya
  • Kentaro Kawanaka
  • Hideaki Soya
Original Paper

Abstract

Brain glycogen stored in astrocytes, a source of lactate as a neuronal energy source, decreases during prolonged exercise with hypoglycemia. However, brain glycogen dynamics during exercise without hypoglycemia remain unknown. Since intense exercise increases brain noradrenaline and serotonin as known inducers for brain glycogenolysis, we hypothesized that brain glycogen decreases with intense exercise not accompanied by hypoglycemia. To test this hypothesis, we employed a well-established acute intense exercise model of swimming in rats. Rats swam for fourteen 20 s bouts with a weight equal to 8 % of their body mass and were sacrificed using high-power (10 kW) microwave irradiation to inactivate brain enzymes for accurate detection of brain glycogen and monoamines. Intense exercise did not alter blood glucose, but did increase blood lactate levels. Immediately after exercise, brain glycogen decreased and brain lactate increased in the hippocampus, cerebellum, cortex, and brainstem. Simultaneously, serotonin turnover in the hippocampus and brainstem mutually increased and were associated with decreased brain glycogen. Intense swimming exercise that does not induce hypoglycemia decreases brain glycogen associated with increased brain lactate, implying an importance of glycogen in brain energetics during intense exercise even without hypoglycemia. Activated serotonergic regulation is a possible underlying mechanism for intense exercise-induced glycogenolysis at least in the hippocampus and brainstem.

Keywords

Intense exercise Brain glycogen Lactate Serotonin Blood glucose 

Supplementary material

11064_2015_1594_MOESM1_ESM.docx (135 kb)
Supplementary material 1 (DOCX 134 kb)

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Takashi Matsui
    • 1
    • 2
  • Shingo Soya
    • 1
  • Kentaro Kawanaka
    • 2
  • Hideaki Soya
    • 1
  1. 1.Laboratory of Exercise Biochemistry and Neuroendocrinology, Institute for Health and Sport SciencesUniversity of TsukubaTsukubaJapan
  2. 2.Department of Health and NutritionNiigata University of Health and WelfareNiigata CityJapan

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