Neurochemical Research

, Volume 39, Issue 7, pp 1332–1337 | Cite as

Prognostic Value of Serum 25-Hydroxyvitamin D in Patients with Stroke

  • Yan Wang
  • Hui Ji
  • Ying Tong
  • Zhuo-bo Zhang
Original Paper


We aimed to evaluate the association between 25-hydroxyvitamin D [25(OH) D] levels and both clinical severity at admission and outcome at discharge in patients with acute ischemic stroke (AIS). From June 2012 to October 2013, consecutive first-ever AIS patients admitted to the Department of Emergency of The Fourth Affiliated Hospital of Harbin Medical University, China were identified. Clinical information was collected. Serum 25(OH) D levels were measured at baseline. Stroke severity was assessed at admission using the National Institutes of Health Stroke Scale (NIHSS) score. Functional outcome was evaluated at discharge using the modified Rankin scale (m-Rankin). Multivariate analyses were performed using logistic regression models. During the study period, 326 patients were diagnosed as AIS and were included in the analysis. Serum 25(OH) D levels reduced with increasing severity of stroke as defined by the NIHSS score. There was a negative correlation between levels of 25(OH) D and the NIHSS (r = − 0.389, P = 0.000). In multivariate analyses, serum 25(OH) D level was an independent prognostic marker of discharge favorable functional outcome and survival [odds ratio 3.96 (2.85–7.87) and 3.36 (2.12–7.08), respectively, P = 0.000 for both, adjusted for NHISS, other predictors and vascular risk factors] in patients with AIS. Serum 25(OH) D levels are a predictor of both severity at admission and favorable functional outcome in patients with AIS. Additional research is needed on vitamin D supplementation to improve the outcome of post-stroke patients.


25-Hydroxyvitamin D Acute ischemic stroke Prognosis 



We thank all the patients, nurses, and physicians who participated in this study and thereby made this work possible. All authors have contributed significantly, and that all authors are in agreement with the content of the manuscript.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of NeurologyThe Fourth Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Department of EmergencySecond Hospital of HarbinHarbinChina
  3. 3.Department of GeriatricsThe Fourth Affiliated Hospital of Harbin Medical UniversityHarbinChina

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