Neurochemical Research

, Volume 38, Issue 1, pp 117–122 | Cite as

The Synergic Effect of Regular Exercise and Resveratrol on Kainate-Induced Oxidative Stress and Seizure Activity in Mice

  • Hee-jae Kim
  • Il-Kon Kim
  • Wook Song
  • Jin Lee
  • Sok Park
Original Paper


The synergic effect of regular exercise and resveratrol, a polyphenolic compound with potent antioxidant activity, was investigated against kainate-induced seizures and oxidative stress in mice. After 6 weeks of swimming training, the total body weight decreased and the blood concentration of lactate stabilized statistically in comparison with the sedentary mice, indicate that the training program increased the aerobic resistance of mice. Kainate (30 mg/kg) evoked seizure activity 5 min after injection, and seizure activity was measured seizure rating scores every 5 min up to 2 h. As previously well known experiments, regular exercise and resveratrol (40 mg/kg, daily supplementation for 6 weeks) have an inhibitory effect on kainate-induced seizure activity and oxidative stress. In particularly, a synergistic cooperation of regular exercise and resveratrol was observed in seizure activity, mortality and oxidative stress especially in SOD activity. These results suggest that regular exercise along with an anti-convulsant agent such as resveratrol could be a more efficient method for the prevention of seizure development than exercise alone.


Resveratrol Regular exercise Oxidative stress Kainate-induced Seizure 



This work was supported by National Research Foundation of Korea Grant funded by the Korean Government (NRF-2012-332-2012A029).


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Hee-jae Kim
    • 1
  • Il-Kon Kim
    • 2
  • Wook Song
    • 1
  • Jin Lee
    • 3
  • Sok Park
    • 2
  1. 1.Health and Exercise Science Laboratory, Institute of Sports ScienceSeoul National UniversitySeoulKorea
  2. 2.Division of Sports Industry & ScienceMokwon UniversityDaejeonKorea
  3. 3.Department of Anatomy and Cell Biology, Collage of MedicineHanyang UniversitySeoulKorea

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