Neurochemical Research

, Volume 37, Issue 12, pp 2805–2813 | Cite as

Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis

  • Sheng Chen
  • Frances Fangjia Lu
  • Philip Seeman
  • Fang LiuEmail author
Original Paper


The substantia nigra plays important roles in the brain function and is critical in the development of many diseases, particularly Parkinson’s disease. Pathological changes of the substantia nigra have also been reported in other neurodegenerative diseases. Using a quantitative proteomic approach, we investigated protein expressions in the substantia nigra of Alzheimer’s disease, Huntington’s disease, and Multiple sclerosis. The expression level of one hundred and four proteins that were identified in at least three samples of each group were compared with the control group, with nineteen, twenty-two and thirteen proteins differentially expressed in Alzheimer’s diseases, Huntington’s disease and Multiple sclerosis respectively. The result indicates that the substantia nigra also undergoes functional adaption or damage in these diseases.


Substantia nigra Quantitative proteomics Alzheimer’s disease Huntington’s disease Multiple sclerosis 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Sheng Chen
    • 1
  • Frances Fangjia Lu
    • 1
  • Philip Seeman
    • 2
  • Fang Liu
    • 1
    Email author
  1. 1.Department of Molecular NeuroscienceCentre for Addiction and Mental HealthTorontoCanada
  2. 2.Department of PharmacologyUniversity of TorontoTorontoCanada

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